Experimental Pythium aphanidermatum Infection in Rabbits.

Autor: Zambrano CG; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil., Braga CQ; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil., Dal Ben V; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil., Silveira JS; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil., Scheid HV; Regional Veterinary Diagnostic Laboratory, Department of Preventive Veterinary Medicine, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, Brazil., Melo LG; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil., Sallis ES; Regional Veterinary Diagnostic Laboratory, Department of Preventive Veterinary Medicine, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, Brazil., Botton SA; Centre for Rural Sciences, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Pereira DI; Laboratory of Mycology, Institute of Biology, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil. Electronic address: danielabrayer@gmail.com.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2022 Jan; Vol. 190, pp. 30-35. Date of Electronic Publication: 2022 Jan 29.
DOI: 10.1016/j.jcpa.2021.12.001
Abstrakt: Pythium aphanidermatum is a common plant pathogen, reportedly capable of human infection. This study investigated whether P. aphanidermatum can infect domestic rabbits. Four rabbits were inoculated with P. aphanidermatum subcutaneously and evaluated for 30 days. Blood and tissue samples were collected from all animals. The animals developed palpable nodules 5-10 days after inoculation. Necropsy revealed caseous nodular lesions characterized histopathologically by pyogranulomatous inflammation containing hyphae in the necrotic areas. P. aphanidermatum was isolated from the caseous material and anti-P. aphanidermatum antibodies were detected by serological examination. This is the first report of experimental P. aphanidermatum infection in mammals. The results demonstrate that this oomycete can produce infection at the inoculation site and induce an immune response. The results suggest that P. aphanidermatum may be undergoing adaptation to vertebrate hosts.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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