| Autor: |
Leavell Y; Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA., Simpson DM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Pain management [Pain Manag] 2022 Jul; Vol. 12 (5), pp. 595-609. Date of Electronic Publication: 2022 Feb 14. |
| DOI: |
10.2217/pmt-2021-0025 |
| Abstrakt: |
Treatment of painful diabetic peripheral neuropathy (PDPN) is challenging and often limited by drug tolerability and adverse effects. This review article focuses on the high-dose (8%) capsaicin patch that allows for improved efficacy and reduced application frequency in comparison to low-dose capsaicin formulations. Systemic absorption is minimal resulting in fewer systemic side effects than first-line oral medications. There is evidence that capsaicin patch treatment is well-tolerated, safe and provides effective pain relief maintained for several weeks; well-powered studies are needed to confirm these findings. The capsaicin 8% patch may benefit patients at high risk for adverse effects from oral medication, polypharmacy or inadequate pain relief from first-line therapies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
