| Autor: |
Chumasov EI; Institute of Experimental Medicine, 12 Akademician Pavlov str., St. Petersburg 197376, Russian Federation.; Saint-Petersburg State University of Veterinary Medicine, 5 Chernigovskaya str., St. Petersburg 196084,Russian Federation, e-mail: ua1ctl@mail.ru., Petrova ES; Institute of Experimental Medicine, 12 Akademician Pavlov str., St. Petersburg 197376, Russian Federation., Korzhevskii DE; Institute of Experimental Medicine, 12 Akademician Pavlov str., St. Petersburg 197376, Russian Federation. |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2021; Vol. 34 (6), pp. 831-840. |
| Abstrakt: |
Using histological methods of staining with toluidine blue, hematoxylin-eosin and immunohistochemical reactions for the PGP 9,5 protein, tyrosine hydroxylase (TH), Iba-1 protein, cellular changes in different parts of the heart of Wistar rats at the age of 18-23 months were studied. In the connective tissue of the heart base, focal inflammatory infiltrates were found, near which PGP 9.5+ and TH+ plexuses, consisting of parasympathetic and sympathetic nerve fibers, were detected. In the area of the valvular heart apparatus, at the border of the anneau fibreux and the myocardium of the right atrium, pathological changes in nerve structures were found: degeneration of nerve fibers and granular destruction varicose axons of the terminal plexus. A close relationship has been established between axons of the terminal nervous network and cells of inflammatory infiltrates and blood capillaries. The features of the localization of neurocellular inflammatory complexes consisting of nerve fibers, blood capillaries and cells participating in the local inflammatory process (mast cells, histiocytes, monocytes, fibroblasts, plasma cells) in various parts of the myocardium in old animals are described. The chronic nature of neurogenic inflammation in the heart during aging has been established. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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