Dental arches in inherited severe isolated growth hormone deficiency.

Autor: Girão RS; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil. Electronic address: herminio@infonet.com.br., Andrade BMR; Division of Speech therapy, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Bittencourt MAV; School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil., Salvatori R; Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA., Silva EV; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Santos ALM; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Cunha MM; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Takeshita WM; Postgraduate Program in Dentistry School of Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira AHA; School of Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Valença EHO; Division of Speech therapy, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira-Santos AA; Division of Nutrition, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira-Neto LA; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
Jazyk: angličtina
Zdroj: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2022 Feb; Vol. 62, pp. 101444. Date of Electronic Publication: 2022 Jan 18.
DOI: 10.1016/j.ghir.2022.101444
Abstrakt: Objectives: The growth of the dental arches depends on GH and insulin-like growth factor type 1 (IGF1), but the consequences of GH deficiency (GHD) on their growth are still unclear, probably due to the acquired etiology of GHD in most described series, often associated with additional pituitary deficits (thyrotrophic, corticotrophic and gonadotrophic hormones), and imperfections of related replacement therapies, which may affect the dental arch growth. To avoid these limitations, we took advantage of a unique cohort of subjects with isolated GH deficiency (IGHD) due the same mutation in the GH releasing hormone receptor gene, living with very low serum GH and low to undetectable circulating IGF1 levels. Our purpose was to analyze the dimensions of maxillary and mandibular dental arches.
Methods: 22 adult IGHD (15 untreated and 7 previously partially treated with GH) and 33 controls were enrolled in a cross-sectional study using the Ortho Insight 3D and MeshMixer software, RESULTS: In untreated IGHD subjects all maxillary arch measures were smaller than controls, while among mandibular arches, only the mandibular canine width and the mandibular arch length were reduced. In partially GH treated subjects only the palate depth, the maxillary canine width, the maxillary and mandibular arch lengths remained smaller than controls.
Conclusions: IGHD reduces the growth of maxillary arch to a greater degree than the mandibular arch, suggesting different control of superior and inferior dental arches. GH treatment increases some of these measures.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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