AHR gene expression and the polymorphism rs2066853 are associated with clinicopathological parameters in colorectal carcinoma.

Autor: Cheng T; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia., Gamage SMK; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia; Department of Anatomy, Faculty of Medicine, University of Peradeniya, Kandy 20404, Sri Lanka., Hewage D; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia., Lu CT; Department of Surgery, Gold Coast University Hospital, Southport, Queensland 4215, Australia., Aktar S; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia; Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh 1902, Bangladesh., Gopalan V; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia. Electronic address: v.gopalan@griffith.edu.au., Lam AK; Cancer Molecular Pathology, School of Medicine & Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia; Pathology Queensland, Gold Coast University Hospital, Southport, Queensland 4215, Australia. Electronic address: a.lam@griffith.edu.au.
Jazyk: angličtina
Zdroj: Human pathology [Hum Pathol] 2022 Apr; Vol. 122, pp. 50-59. Date of Electronic Publication: 2022 Feb 09.
DOI: 10.1016/j.humpath.2022.02.001
Abstrakt: The relationship between red and processed meat and its risk toward colorectal carcinoma (CRC) is not fully explored in literature. Polycyclic aromatic hydrocarbons (PAHs) are procarcinogenic molecules that are ingested with meat cooked at high temperatures. The metabolic conversion of PAHs to carcinogenic diol epoxides is in part mediated by the aryl hydrocarbon receptor (AhR)-dependent induction of CYP1A1. This study aims to examine the expression profiles and polymorphisms of the AHR (aryl hydrocarbon receptor) gene which is involved in the metabolic conversion of PAHs in patients with CRC. Genetic analysis was done in matched cancer and non-neoplastic tissues from 79 patients diagnosed with CRCs. Low AHR mRNA expression was associated with mucinous colorectal adenocarcinoma. Exon 10 of AHR showed that 27% of patients had the rs2066853 single-nucleotide polymorphism resulting in an arginine-to-lysine change at codon 554. This variant was significantly associated with a lower likelihood of perineural invasion, presence of synchronous cancer, and multiple colorectal polyps. Furthermore, rs2066853 individuals were significantly more likely to be of more advanced age and have a more favorable tumor grade and pathological stage. These results imply the pathogenic roles of AHR in PAH-associated colorectal carcinogenesis.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: