Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network.

Autor: Pinot de Moira A; Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: anpi@sund.ku.dk., Strandberg-Larsen K; Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Bishop T; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Pedersen M; Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Avraam D; Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom., Cadman T; Population Health Science, Bristol Medical School, Bristol, United Kingdom; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom., Calas L; Université de Paris, Centre for Research in Epidemiology and Statistics, INSERM, INRAE, Paris, France., Casas M; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain., de Lauzon Guillain B; Université de Paris, Centre for Research in Epidemiology and Statistics, INSERM, INRAE, Paris, France., Elhakeem A; Population Health Science, Bristol Medical School, Bristol, United Kingdom; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom., Esplugues A; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Department of Nursing, University of Valencia, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, The Foundation for the Promotion of Health and Biomedical Research of Valencia Region, Universitat Jaume I-Universitat de València, Valencia, Spain., Estarlich M; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Department of Nursing, University of Valencia, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, The Foundation for the Promotion of Health and Biomedical Research of Valencia Region, Universitat Jaume I-Universitat de València, Valencia, Spain., Foong RE; Telethon Kids Institute, Perth, Australia; School of Allied Health, Curtin University, Perth, Australia., Haakma S; Genomics Coordination Center, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Harris JR; Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Huang RC; Telethon Kids Institute, Perth, Australia., Inskip H; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom., Lertxundi A; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Basque Country, Leioa, Spain; Biodonostia Health Research Institute, San Sebastian, Spain., Mensink-Bout SM; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Nader JLT; Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway., Pizzi C; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Popovic M; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy., Salika T; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom., Sunyer J; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Imim-ParcSalutMar, Spain., Van Meel ER; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Swertz MA; Genomics Coordination Center, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Jaddoe VWV; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Burton P; Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom., Duijts L; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Nybo Andersen AM; Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2022 Jul; Vol. 150 (1), pp. 82-92. Date of Electronic Publication: 2022 Feb 10.
DOI: 10.1016/j.jaci.2022.01.023
Abstrakt: Background: Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet, timing, and degree of exposure.
Objective: Our aim was to study associations of early-life cat and dog ownership with asthma in school-aged children, including the role of type (cat vs dog), timing (never, prenatal, or early childhood), and degree of ownership (number of pets owned), and the role of allergic sensitization.
Methods: We used harmonized data from 77,434 mother-child dyads from 9 birth cohorts in the European Union Child Cohort Network when the child was 5 to 11 years old. Associations were examined through the DataSHIELD platform by using adjusted logistic regression models, which were fitted separately for each cohort and combined by using random effects meta-analysis.
Results: The prevalence of early-life cat and dog ownership ranged from 12% to 45% and 7% to 47%, respectively, and the prevalence of asthma ranged from 2% to 20%. There was no overall association between either cat or dog ownership and asthma (odds ratio [OR] = 0.97 [95% CI = 0.87-1.09] and 0.92 [95% CI = 0.85-1.01], respectively). Timing and degree of ownership did not strongly influence associations. Cat and dog ownership were also not associated with cat- and dog-specific allergic sensitization (OR = 0.92 [95% CI = 0.75-1.13] and 0.93 [95% CI = 0.57-1.54], respectively). However, cat- and dog-specific allergic sensitization was strongly associated with school-age asthma (OR = 6.69 [95% CI = 4.91-9.10] and 5.98 [95% CI = 3.14-11.36], respectively). There was also some indication of an interaction between ownership and sensitization, suggesting that ownership may exacerbate the risks associated with pet-specific sensitization but offer some protection against asthma in the absence of sensitization.
Conclusion: Our findings do not support early-life cat and dog ownership in themselves increasing the risk of school-age asthma, but they do suggest that ownership may potentially exacerbate the risks associated with cat- and dog-specific allergic sensitization.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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