Lauric acid bilayer-functionalized iron oxide nanoparticles disrupt early development of freshwater snail Biomphalaria glabrata (Say, 1818).

Autor: Pena RV; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás CEP 74605050, Brazil., Machado RC; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás CEP 74605050, Brazil., Caixeta MB; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás CEP 74605050, Brazil., Araújo PS; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás CEP 74605050, Brazil., de Oliveira EC; Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., da Silva SM; Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Rocha TL; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás CEP 74605050, Brazil. Electronic address: thiagorochabio20@ufg.br.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2022 May; Vol. 229, pp. 106362. Date of Electronic Publication: 2022 Feb 09.
DOI: 10.1016/j.actatropica.2022.106362
Abstrakt: Iron oxide nanoparticles (IONPs) have been indicated for the control of parasites and intermediate hosts, as well as applications in several sectors of nanomedicine. However, knowledge regarding its toxicity, mechanisms of action and the role of functionalization in gastropods that act as intermediate hosts of neglected disease parasites is still scarce. The present study aimed to evaluate the toxicity of lauric acid bilayer-functionalized IONPs (LA-IONPs), lauric acid isolated (LA) and iron ions in embryos and newly-hatched Biomphalaria glabrata. The snails were exposed to different concentrations of IONPs, LA and iron ions (1.0-97.65 mg L -1 ) during 144 h (embryos) and 96 h (newly-hatched) and multiple parameters were analyzed, such as mortality, hatching rate, developmental delay, and morphological changes. The results showed that both iron forms (LA-IONPs and iron ions) and LA promoted mortality, hatching inhibition and morphological changes in snail embryos in a concentration-dependent patterns. Embryos also showed iron bioaccumulation after exposure to both iron forms. High toxicity was observed in newly-hatched snails compared to embryos, indicating the protective role of ovigerous masses during the early developmental stages. LA induced high developmental toxicity compared to LA-IONPs and iron ions. Results showed the molluscicide activity of LA-IONPs and isolated LA, indicating their potential use as molluscicide in the snail control program.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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