L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task.

Autor: Riedel P; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany., Domachowska IM; Department of Psychology, Technische Universität Dresden, Zellescher Weg 17, 01069, Dresden, Germany., Lee Y; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany., Neukam PT; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany., Tönges L; Department of Neurology, Ruhr University Bochum, St. Josef-Hospital, Gudrunstraße 56, 44791, Bochum, Germany., Li SC; Department of Psychology, Technische Universität Dresden, Zellescher Weg 17, 01069, Dresden, Germany.; Centre for Tactile Internet With Human-in-the-Loop, Technische Universität Dresden, Georg-Schumman-Str. 9, 01187, Dresden, Germany., Goschke T; Department of Psychology, Technische Universität Dresden, Zellescher Weg 17, 01069, Dresden, Germany., Smolka MN; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. michael.smolka@tu-dresden.de.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2022 Mar; Vol. 239 (3), pp. 867-885. Date of Electronic Publication: 2022 Feb 11.
DOI: 10.1007/s00213-022-06077-w
Abstrakt: Rationale: The cognitive control dilemma describes the necessity to balance two antagonistic modes of attention: stability and flexibility. Stability refers to goal-directed thought, feeling, or action and flexibility refers to the complementary ability to adapt to an ever-changing environment. Their balance is thought to be maintained by neurotransmitters such as dopamine, most likely in a U-shaped rather than linear manner. However, in humans, studies on the stability-flexibility balance using a dopaminergic agent and/or measurement of brain dopamine are scarce.
Objective: The study aimed to investigate the causal involvement of dopamine in the stability-flexibility balance and the nature of this relationship in humans.
Methods: Distractibility was assessed as the difference in reaction time (RT) between distractor and non-distractor trials in a visual search task. In a randomized, placebo-controlled, double-blind, crossover study, 65 healthy participants performed the task under placebo and a dopamine precursor (L-DOPA). Using 18 F-DOPA-PET, dopamine availability in the striatum was examined at baseline to investigate its relationship to the RT distractor effect and to the L-DOPA-induced change of the RT distractor effect.
Results: There was a pronounced RT distractor effect in the placebo session that increased under L-DOPA. Neither the RT distractor effect in the placebo session nor the magnitude of its L-DOPA-induced increase were related to baseline striatal dopamine.
Conclusions: L-DOPA administration shifted the stability-flexibility balance towards attentional capture by distractors, suggesting causal involvement of dopamine. This finding is consistent with current theories of prefrontal cortex dopamine function. Current data can neither confirm nor falsify the inverted U-shaped function hypothesis with regard to cognitive control.
(© 2022. The Author(s).)
Databáze: MEDLINE
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