Hybrid [ 18 F]-F-DOPA PET/MRI Interpretation Criteria and Scores for Glioma Follow-up After Radiotherapy.

Autor: Bertaux M; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France. marc.bertaux@gmail.com., Berenbaum A; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France., Di Stefano AL; Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, 75013, Paris, France., Rozenblum L; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France., Soret M; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France.; LIB, INSERM U1146, Sorbonne Université, 75013, Paris, France., Bergeret S; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France., Hoang-Xuan K; Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, 75013, Paris, France., Tainturier LE; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France., Sgard B; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France., Habert MO; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France.; LIB, INSERM U1146, Sorbonne Université, 75013, Paris, France., Delattre JY; Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, 75013, Paris, France., Dehais C; Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, 75013, Paris, France., Idbaih A; Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, 75013, Paris, France., Pyatigorskaya N; Service de neuroradiologie, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France.; INSERM U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06, UMRS 1127, CNRS UMR 7225, Institut du Cerveau et , de, la Moelle épinière-ICM, Paris, France., Kas A; Service de médecine nucléaire, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013, Paris, France.; LIB, INSERM U1146, Sorbonne Université, 75013, Paris, France.
Jazyk: angličtina
Zdroj: Clinical neuroradiology [Clin Neuroradiol] 2022 Sep; Vol. 32 (3), pp. 735-747. Date of Electronic Publication: 2022 Feb 11.
DOI: 10.1007/s00062-022-01139-0
Abstrakt: Objective: 18 F‑fluoro-L‑3,4‑dihydroxyphenylalanine positron emission tomography (F‑DOPA PET) is used in glioma follow-up after radiotherapy to discriminate treatment-related changes (TRC) from tumor progression (TP). We compared the performances of a combined PET and MRI analysis with F‑DOPA current standard of interpretation.
Methods: We included 76 consecutive patients showing at least one gadolinium-enhanced lesion on the T1‑w MRI sequence (T1G). Two nuclear medicine physicians blindly analyzed PET/MRI images. In addition to the conventional PET analysis, they looked for F‑DOPA uptake(s) outside T1G-enhanced areas (T1G/PET), in the white matter (WM/PET), for T1G-enhanced lesion(s) without sufficiently concordant F‑DOPA uptake (T1G+/PET), and F‑DOPA uptake(s) away from hemorrhagic changes as shown with a susceptibility weighted imaging sequence (SWI/PET). We measured lesions' F‑DOPA uptake ratio using healthy brain background (TBR) and striatum (T/S) as references, and lesions' perfusion with arterial spin labelling cerebral blood flow maps (rCBF). Scores were determined by logistic regression.
Results: 53 and 23 patients were diagnosed with TP and TRC, respectively. The accuracies were 74% for T/S, 76% for TBR, and 84% for rCBF, with best cut-off values of 1.3, 3.7 and 1.25, respectively. For hybrid variables, best accuracies were obtained with conventional analysis (82%), T1G+/PET (82%) and SWI/PET (81%). T1G+/PET, SWI/PET and rCBF ≥ 1.25 were selected to construct a 3-point score. It outperformed conventional analysis and rCBF with an AUC of 0.94 and an accuracy of 87%.
Conclusions: Our scoring approach combining F‑DOPA PET and MRI provided better accuracy than conventional PET analyses for distinguishing TP from TRC in our patients after radiation therapy.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
Externí odkaz: