Recent advances in the structural biology of encapsulin bacterial nanocompartments.
| Autor: | Wiryaman T; University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA., Toor N; University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of structural biology: X [J Struct Biol X] 2022 Jan 23; Vol. 6, pp. 100062. Date of Electronic Publication: 2022 Jan 23 (Print Publication: 2022). |
| DOI: | 10.1016/j.yjsbx.2022.100062 |
| Abstrakt: | Large capsid-like nanocompartments called encapsulins are common in bacteria and archaea and contain cargo proteins with diverse functions. Advances in cryo-electron microscopy have enabled structure determination of many encapsulins in recent years. Here we summarize findings from recent encapsulin structures that have significant implications for their biological roles. We also compare important features such as the E-loop, cargo-peptide binding site, and the fivefold axis channel in different structures. In addition, we describe the discovery of a flavin-binding pocket within the encapsulin shell that may reveal a role for this nanocompartment in iron metabolism. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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