Fatal fungemia by biofilm-producing Trichosporon asahii in a liver transplant candidate.

Autor:	Tiseo G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Fais R; Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Forniti A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Melandro F; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy., Tavanti A; Department of Biology, University of Pisa, Pisa, Italy., Ghelardi E; Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., De Simone P; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.; Department of Surgical, Medical, Molecular Pathology and Intensive Care, University of Pisa, Pisa, Italy., Falcone M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Lupetti A; Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Jazyk:	angličtina
Zdroj:	Le infezioni in medicina [Infez Med] 2021 Sep 10; Vol. 29 (3), pp. 464-468. Date of Electronic Publication: 2021 Sep 10 (Print Publication: 2021).
DOI:	10.53854/liim-2903-18
Abstrakt:	Acute-on-chronic liver failure (ACLF) is often associated with a dismal outcome. Infections might preclude access to liver transplantation (LT) for these patients, further reducing their chance of survival. We report the case of a patient with ACLF who died before LT for biofilm-producing Trichosporon asahii fungemia. The patient early started antifungal therapy with anidulafungin, but T. asahii was not susceptible to echinocandins, delaying the start of active antifungal therapy. Although rare, invasive infections by Trichosporon spp. are associated with high mortality rates due to low antimicrobial susceptibility and production of biofilms on indwelling devices. Early diagnosis and treatment are crucial to reduce mortality and enhance patient survival. Competing Interests: Conflict of interest None to declare. (Copyright © 2016 - 2021 InfezMed.)
Databáze:	MEDLINE
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