Potential Mechanisms of Acupuncture for Functional Dyspepsia Based on Pathophysiology.

Autor:	Yang NN; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Tan CX; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Lin LL; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Su XT; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Li YJ; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Qi LY; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Wang Y; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Yang JW; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China., Liu CZ; International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture, Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2022 Jan 25; Vol. 15, pp. 781215. Date of Electronic Publication: 2022 Jan 25 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.781215
Abstrakt:	Functional dyspepsia (FD), a common disorder of gastrointestinal function, originated from the gastroduodenum. Although the therapeutic effect of acupuncture has been investigated by various high-quality randomized controlled trials, the potential mechanisms showed obvious heterogeneity. This review summarized the potential mechanisms of acupuncture on FD in order to guide for future laboratory and clinical studies. Here, we argued that the primary cause of FD was gastroduodenal low-grade inflammation and acid exposure, which impaired mucosal integrity, caused brain-gut axis dysfunction, and impaired brain network connectivity, all of which generated various symptom patterns. Overall the clinical studies indicated that acupuncture was a promising treatment to alleviate symptoms in FD patients, whose efficacy was influenced by acupoints and individual variance. Mechanistically, studies with animal models of FD and patients have shown that acupuncture, a non-invasive strategy for nerve stimulation, may have the potential to control intestinal inflammation and suppress acid-secretion via different somatic autonomic reflex pathways, regulate the brain-gut axis through intestinal microbiota, and has the potential to ameliorate FD-symptoms. The cumulative evidence demonstrated that acupuncture is a promising treatment to alleviate symptoms of FD patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Yang, Tan, Lin, Su, Li, Qi, Wang, Yang and Liu.)
Databáze:	MEDLINE
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