Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling.

Autor:	Lo Presti J; Department of Woman's and Child's Health, University of Padova, Padova, Italy., Galderisi A; Department of Woman's and Child's Health, University of Padova, Padova, Italy.; Hôpital Necker-Enfants Malades, Paris, France., Doyle FJ 3rd; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Zisser HC; Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA., Dassau E; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Renard E; Department of Endocrinology, Diabetes, Nutrition and INSERM Clinical Investigation Center 1411, University Hospital of Montpellier, Montpellier, France.; Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, Montpellier, France., Toffanin C; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy., Cobelli C; Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Jazyk:	angličtina
Zdroj:	Journal of diabetes science and technology [J Diabetes Sci Technol] 2023 May; Vol. 17 (3), pp. 751-756. Date of Electronic Publication: 2022 Feb 10.
DOI:	10.1177/19322968221076559
Abstrakt:	Background: Intraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient. Methods: Relying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC. Results: Intraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma. Conclusion: Intraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual-not actual-transit space for insulin delivery.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu