Comparative Genomics Elucidates the Origin of a Supergene Controlling Floral Heteromorphism.

Autor:	Potente G; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.; BaseClear BV, Leiden, The Netherlands.; Zurich-Basel Plant Science Center, Zurich, Switzerland., Léveillé-Bourret É; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.; Département de Sciences Biologiques, Institut de Recherche en Biologie Végétale, Université de Montréal, Montréal, Canada., Yousefi N; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland., Choudhury RR; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland., Keller B; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland., Diop SI; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.; BaseClear BV, Leiden, The Netherlands.; Zurich-Basel Plant Science Center, Zurich, Switzerland., Duijsings D; BaseClear BV, Leiden, The Netherlands., Pirovano W; BaseClear BV, Leiden, The Netherlands., Lenhard M; Institute for Biochemistry and Biology, University of Potsdam, Potsdam-Golm, Germany., Szövényi P; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.; Zurich-Basel Plant Science Center, Zurich, Switzerland., Conti E; Department of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.; Zurich-Basel Plant Science Center, Zurich, Switzerland.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2022 Feb 03; Vol. 39 (2).
DOI:	10.1093/molbev/msac035
Abstrakt:	Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula? (© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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