Prospective Memory Influences Social Functioning in People With First-Episode Schizophrenia: A Network Analysis and Longitudinal Study.

Autor:	Lui SSY; Department of Psychiatry, University of Hong Kong, Hong Kong Special Administrative Region, China.; Castle Peak Hospital, Hong Kong Special Administration Region, China.; These authors contributed equally to this study.; Corresponding authors: Simon S. Y. Lui, PhD, FRCPsych, Department of Psychiatry, University of Hong Kong, Hong Kong Special Administrative Region, China (lsy570@hku.hk); and Raymond C. K. Chan, PhD, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Rd, Beijing 100101, China (rckchan@psych.ac.cn)., Zhang RT; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Department of Psychology, School of Education Science, Hunan Normal University, Changsha, China.; Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Changsha, China.; These authors contributed equally to this study., Lau WYS; Castle Peak Hospital, Hong Kong Special Administration Region, China., Liu ACY; Castle Peak Hospital, Hong Kong Special Administration Region, China., Chui WWH; Castle Peak Hospital, Hong Kong Special Administration Region, China., Wang Y; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Tsang KCM; Castle Peak Hospital, Hong Kong Special Administration Region, China., Yeung HKH; Castle Peak Hospital, Hong Kong Special Administration Region, China., Cheung EFC; Castle Peak Hospital, Hong Kong Special Administration Region, China., Chan RCK; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Corresponding authors: Simon S. Y. Lui, PhD, FRCPsych, Department of Psychiatry, University of Hong Kong, Hong Kong Special Administrative Region, China (lsy570@hku.hk); and Raymond C. K. Chan, PhD, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Rd, Beijing 100101, China (rckchan@psych.ac.cn).
Jazyk:	angličtina
Zdroj:	The Journal of clinical psychiatry [J Clin Psychiatry] 2022 Feb 08; Vol. 83 (2). Date of Electronic Publication: 2022 Feb 08.
DOI:	10.4088/JCP.21m14114
Abstrakt:	Background: Prospective memory (PM) impairment is associated with impaired social functioning, but evidence is limited to chronic schizophrenia samples and cross-sectional design. The aim of this study was to utilize network analysis to address the complex interplay between PM, psychopathology, and functional outcome. Methods: This longitudinal study recruited 119 people with first-episode DSM-IV schizophrenia and followed up with them for 2 to 6 years. PM and working memory were assessed at baseline (in 2010-2015) using valid computerized tasks and the Letter-Number Span Test, respectively. Psychopathology and social functioning were assessed at endpoint (in 2016-2017) using the Positive and Negative Syndrome Scale (PANSS) and the Social and Occupational Functioning Assessment Scale (SOFAS), respectively. Network analysis examined the effect of baseline PM on SOFAS while accounting for the effects of psychopathology. Results: The resultant network showed that social functioning, PANSS positive symptoms, and PANSS general symptoms clustered together, whereas time-based and event-based PM and working memory formed another cluster. Time-based PM linked event-based PM and working memory with social functioning. Time-based PM (expected influence [EI] = 0.69), event-based PM (EI = 0.65), and working memory (EI = 0.83) demonstrated high values of expected influence, but social functioning (variance explained = 0.685) and PANSS negative (variance explained = 0.657) and general (variance explained = 0.583) subscales demonstrated high values of predictability. Conclusions: Time-based PM is the central node linking neurocognitive functions with social functioning. PM and working memory are "target" nodes for interventions bringing changes to the network, whereas social functioning and psychopathology are "malleable" nodes. PM and working memory are promising intervention targets for functional recovery in schizophrenia. (© Copyright 2022 Physicians Postgraduate Press, Inc.)
Databáze:	MEDLINE
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