Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study.

Autor:	Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Centre for Non-Communicable Disease Research, Dhaka, Bangladesh., Noh MFM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Ismail SR; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., van Daalen KR; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Kamaruddin PSNM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Zulkiply SH; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Azizul NH; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Khalid NM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Ali A; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Idris IM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Mei YS; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Abdullah SR; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Faridus N; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Yusof NAM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Yusoff NNFM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Jamal R; UKM Medical Molecular Biological Institute, Kuala Lumpur, Malaysia., Rahim AAA; National Heart Institute, Kuala Lumpur, Malaysia., Ghapar AKA; Department of Cardiology, Hospital Serdang, Selangor, Malaysia., Radhakrishnan AK; Jeffery Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia., Fong AYY; Department of Cardiology, Sarawak Heart Centre, Kota Samarahan, Malaysia.; Clinical Research Centre, Institute for Clinical Research, Sarawak General Hospital, Kuching, Malaysia., Ismail O; Department of Cardiology, Hospital Pulau Pinang, Pulau Pinang, Malaysia., Krishinan S; Department of Cardiology, Hospital Sultanah Bahiyah, Kedah, Malaysia., Lee CY; Department of Cardiology, Hospital Sultanah Aminah, Johor, Malaysia., Bang LH; Department of Cardiology & Clinical Research Centre, Hospital Queen Elizabeth II, Sabah, Malaysia., Mageswaren E; Department of General Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia., Mahendran K; Department of General Medicine & Clinical Research Centre, Hospital Melaka, Melaka, Malaysia., Amin NHM; Department of General Medicine, Hospital Raja Permaisuri Bainun, Perak, Malaysia., Muthusamy G; Department of General Medicine, Hospital Shah Alam, Selangor, Malaysia., Jin AOH; Department of General Medicine, Hospital Tuanku Fauziah, Perlis, Malaysia., Ramli AW; Department of Cardiology, Hospital Sultanah Nur Zahirah, Terengganu, Malaysia., Ross NT; Department of General Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Ruhani AI; Department of Cardiology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia., Yahya M; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Yusoff Y; Department of General Medicine, Hospital Sungai Buloh, Selangor, Malaysia., Abidin SKZ; Department of General Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia., Amado L; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Bolton T; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom., Weston S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Crawte J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Ovenden N; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Michielsen A; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Monower MM; National Heart Foundation Hospital & Research Institute, Mirpur, Dhaka, Bangladesh., Mahiyuddin WRW; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Wood A; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom., Sulaiman NS; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	JMIR research protocols [JMIR Res Protoc] 2022 Feb 10; Vol. 11 (2), pp. e31885. Date of Electronic Publication: 2022 Feb 10.
DOI:	10.2196/31885
Abstrakt:	Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. Objective: The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. Methods: By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Results: Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P<.001), previous smoking (OR 1.34, 95% CI 1.12-1.60; P=.001), a history of high blood pressure (OR 2.13, 95% CI 1.86-2.44; P<.001), a history of diabetes mellitus (OR 2.72, 95% CI 2.34-3.17; P<.001), a family history of coronary heart disease (OR 1.28, 95% CI 1.07-1.55; P=.009), and obesity (BMI >30 kg/m 2 ; OR 1.19, 95% CI 1.05-1.34; P=.009) were associated with MI in age- and sex-adjusted models. Conclusions: The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an understudied Southeast Asian population. It should help to hasten the discovery of disease-causing pathways and inform regionally appropriate strategies that optimize public health action. International Registered Report Identifier (irrid): RR1-10.2196/31885. (©Rajiv Chowdhury, Mohd Fairulnizal Md Noh, Sophia Rasheeqa Ismail, Kim Robin van Daalen, Puteri Sofia Nadira Megat Kamaruddin, Siti Hafizah Zulkiply, Nur Hayati Azizul, Norhayati Mustafa Khalid, Azizan Ali, Izyan Mohd Idris, Yong Shih Mei, Shazana Rifham Abdullah, Norfashihah Faridus, Nur Azirah Md Yusof, Nur Najwa Farahin M Yusoff, Rahman Jamal, Aizai Azan Abdul Rahim, Abdul Kahar Abdul Ghapar, Ammu Kutty Radhakrishnan, Alan Yean Yip Fong, Omar Ismail, Saravanan Krishinan, Chuey Yan Lee, Liew Houng Bang, Eashwary Mageswaren, Kauthaman Mahendran, Nor Hanim Mohd Amin, Gunavathy Muthusamy, Aaron Ong Hean Jin, Ahmad Wazi Ramli, Noel Thomas Ross, Anwar Irawan Ruhani, Mansor Yahya, Yusniza Yusoff, Siti Khairani Zainal Abidin, Laryssa Amado, Thomas Bolton, Sophie Weston, Jason Crawte, Niko Ovenden, Ank Michielsen, Md Mostafa Monower, Wan Rozita Wan Mahiyuddin, Angela Wood, Emanuele Di Angelantonio, Nur Suffia Sulaiman, John Danesh, Adam S Butterworth. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 10.02.2022.)
Databáze:	MEDLINE
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