Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome.

Autor:	Shilts MH; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Rosas-Salazar C; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States., Strickland BA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Kimura KS; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States., Asad M; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Sehanobish E; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Freeman MH; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States., Wessinger BC; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States., Gupta V; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States., Brown HM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Boone HH; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Patel V; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Barbi M; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Bottalico D; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., O'Neill M; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Akbar N; Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States., Rajagopala SV; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Mallal S; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Phillips E; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Turner JH; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Jerschow E; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States., Das SR; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Jan 24; Vol. 11, pp. 781968. Date of Electronic Publication: 2022 Jan 24 (Print Publication: 2021).
DOI:	10.3389/fcimb.2021.781968
Abstrakt:	Background: The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited. Objective: Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity. Methods: Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19. Results: URT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium _unclassified.ASV0002, consistently decreased as COVID-19 severity increased. Conclusions: We observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Shilts, Rosas-Salazar, Strickland, Kimura, Asad, Sehanobish, Freeman, Wessinger, Gupta, Brown, Boone, Patel, Barbi, Bottalico, O’Neill, Akbar, Rajagopala, Mallal, Phillips, Turner, Jerschow and Das.)
Databáze:	MEDLINE
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