Association and Risk Factors of Osteonecrosis of Femoral Head in Sickle Cell Disease: A Systematic Review.

Autor: Leandro MP; Hospital Geral Ernesto Simões Filho, Praça Conselheiro João Alfredo, s/n - Caixa D'agua, Salvador-Bahia, 40301-155 Brazil., De Sá CKC; Hospital Geral Ernesto Simões Filho, Praça Conselheiro João Alfredo, s/n - Caixa D'agua, Salvador-Bahia, 40301-155 Brazil., Filho DPS; Hospital Geral Ernesto Simões Filho, Praça Conselheiro João Alfredo, s/n - Caixa D'agua, Salvador-Bahia, 40301-155 Brazil., De Souza LAA; Hospital Geral Ernesto Simões Filho, Praça Conselheiro João Alfredo, s/n - Caixa D'agua, Salvador-Bahia, 40301-155 Brazil., Salles C; Bahiana School of Medicine and Public Health, Salvador-Bahia, Brazil., Tenório MCC; Bahiana School of Medicine and Public Health, Salvador-Bahia, Brazil., Paz CLDSL; Federal University of Bahia, Bahia, Brazil., Matos MAA; Bahiana School of Medicine and Public Health, Salvador-Bahia, Brazil.
Jazyk: angličtina
Zdroj: Indian journal of orthopaedics [Indian J Orthop] 2021 Aug 04; Vol. 56 (2), pp. 216-225. Date of Electronic Publication: 2021 Aug 04 (Print Publication: 2022).
DOI: 10.1007/s43465-021-00469-4
Abstrakt: Objective: The objective was to evaluate the level of evidence about the associated factors and the risk factors of osteonecrosis of femoral head (ONFH) in sickle cell individuals.
Methods: The review was based on the search and selection of studies available in the electronic databases PubMed, SCIELO, LILACS, BVS. As descriptors, the terms of Medical Subject Headings (MeSH) and Health Sciences Descriptors (DeCS) corresponding to "Osteonecrosis", "Necrosis avascular" and "Aseptic necrosis" and "Femoral head" and "sickle cell disease" and "risk factor" and "predictor".
Results: Among clinical and laboratorial factors the most promising risk factors were the severity of sickle cell disease and acute chest syndrome. As a result, from studies of a moderate level of quality, blood pressure, body weight, previous trauma, haemoglobin to haematocrit ratio (Hb/HCT), and number of hospitalizations can be highlighted. Others, such as genetic markers and male gender, have also been positively associated in lower quality studies.
Conclusion: For a better clarification of what the risk factors are for the ONFH, it is necessary to study with populations of different origins, different ages, different profiles of Hb, which present greater methodological rigor and perform a multivariate analysis to control confounding factors. Further study is also needed to understand the genetic determinants of ONFH.
Competing Interests: Conflict of interestThe authors declare that there is no conflict of interest.
(© Indian Orthopaedics Association 2021.)
Databáze: MEDLINE
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