ATP synthase: a moonlighting enzyme with unprecedented functions.

Autor: Vigneau JN; Dép. de chimie, Université Laval, Québec, QC G1V0A6, Canada. cherif.matta@msvu.ca.; Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay, Orsay 91400, France., Fahimi P; Dép. de chimie, Université Laval, Québec, QC G1V0A6, Canada. cherif.matta@msvu.ca.; Dept. of Chemistry & Physics, Mount Saint Vincent University, Halifax, NS B3M2J6, Canada., Ebert M; Chemical Computing Group (CCG), Sherbrooke Street West, Montreal, QC H3A2R7, Canada., Cheng Y; Dept. of Chemistry, Saint Mary's University, Halifax, NS B3H3C3, Canada., Tannahill C; Dept. of Mathematics & Computing Science, Saint Mary's University, Halifax, NS B3H3C3, Canada., Muir P; Dept. of Mathematics & Computing Science, Saint Mary's University, Halifax, NS B3H3C3, Canada., Nguyen-Dang TT; Dép. de chimie, Université Laval, Québec, QC G1V0A6, Canada. cherif.matta@msvu.ca., Matta CF; Dép. de chimie, Université Laval, Québec, QC G1V0A6, Canada. cherif.matta@msvu.ca.; Dept. of Chemistry & Physics, Mount Saint Vincent University, Halifax, NS B3M2J6, Canada.; Dept. of Chemistry, Saint Mary's University, Halifax, NS B3H3C3, Canada.; Dept. of Chemistry, Dalhousie University, Halifax, NS B3H4J3, Canada.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Feb 22; Vol. 58 (16), pp. 2650-2653. Date of Electronic Publication: 2022 Feb 22.
DOI: 10.1039/d1cc06793a
Abstrakt: ATP synthase's intrinsic molecular electrostatic potential (MESP) adds constructively to, and hence reinforces, the chemiosmotic voltage. This ATP synthase voltage represents a new free energy term that appears to have been overlooked. This term is at least roughly equal in order of magnitude and opposite in sign to the energy needed to be dissipated as a Maxwell's demon (Landauer principle).
Databáze: MEDLINE