Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela.

Autor:	Bermudez V; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia.; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Rojas J; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela.; Pulmonary and Critical Care Medicine Department, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Salazar J; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Martinez MS; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Olivar LC; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Calvo MJ; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Mindiola A; Geriatric Research Education and Clinical Center (GRECC), U.S Department of Veterans Affairs, Miami, FL, USA., Añez R; Endocrine and Metabolic Diseases Research Center, The University of Zulia, Maracaibo, Venezuela., Wilches-Duran S; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Cerda M; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Graterol M; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Graterol R; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Hernandez JD; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Garicano C; Grupo de Investigación Altos Estudios de Frontera (ALEF), Universidad Simón Bolívar, Cucuta, Colombia., Velasco M; Department of Pharmacology, 'JM Vargas' Medical School, Central University of Venezuela, Caracas, Venezuela.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2018 Feb 27; Vol. 7, pp. 230. Date of Electronic Publication: 2018 Feb 27 (Print Publication: 2018).
DOI:	10.12688/f1000research.13897.2
Abstrakt:	Background: In 1980, Reuben Andresen observed that in certain individuals, obesity did not increase mortality, introducing an atypical phenotype called "healthy obese". Other studies reported that 10-15 % of lean individuals presented insulin resistance, hyperglycemia and dyslipidemia. The objective of this study was to evaluate biochemical and clinical characteristics of metabolic phenotypes in Maracaibo city. Methods: A descriptive, cross-sectional sub-analysis of The Maracaibo City Metabolic Syndrome Prevalence Study, with a randomized multistage sampling was performed including 1226 non diabetic individuals from both sexes. For phenotype definition, the subjects were first classified according to their BMI into Normal-Weight, Overweight and Obese; then divided in metabolically healthy and unhealthy using a two-step analysis cluster being predictive variables: HOMA2-IR, HOMA2-βcell, triglycerides. To evaluate the relationship with coronary risk, a multiple logistic regression model was performed. Results: In the studied population, 43.9% (n=538) were healthy normal weight, 5.2% (n=64) unhealthy normal weight, 17.4% (n=217) healthy obese and 33.5% (n=411) unhealthy obese subjects. Atypical phenotypes, Metabolically Unhealthy Normal-Weight (MUNW) was more frequent in males (56.3%), whereas Metabolically Unhealthy Obese (MUO) was more frequent in females (51.3%). This phenotypes had a higher coronary event risk, especially for obese individuals (MHO: OR=1.85 CI95%: 1.11-3.09; p=0.02 and MUO: OR=2.09 CI95%: 1.34-3.28; p<0.01). Conclusion: Individuals with atypical metabolic phenotypes are common in Maracaibo city. Related factors may include insulin resistance, basal glucose, and triglycerides levels. Lastly, obese subjects show a higher coronary event risk even those with normal metabolic status. Competing Interests: No competing interests were disclosed. (Copyright: © 2019 Bermudez V et al.)
Databáze:	MEDLINE
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