Solubility of favipiravir (as an anti-COVID-19) in supercritical carbon dioxide: An experimental analysis and thermodynamic modeling.

Autor: Sajadian SA; South Zagros Oil and Gas Production, National Iranian Oil Company, 7135717991 Shiraz, Iran.; Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran., Ardestani NS; Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, 14155-4777 Karaj, Iran., Esfandiari N; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran., Askarizadeh M; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran., Jouyban A; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.; Faculty of Pharmacy, Near East University, PO BOX: 99138, Mersin 10, Nicosia, North Cyprus,Turkey.
Jazyk: angličtina
Zdroj: The Journal of supercritical fluids [J Supercrit Fluids] 2022 Apr; Vol. 183, pp. 105539. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1016/j.supflu.2022.105539
Abstrakt: Favipiravir is one of the most commonly prescribed drugs in the treatment of COVID-19 in the early stages of the disease. In this work, the solubility of favipiravir was measured in supercritical CO 2 at temperatures ranging from 308 to 338 K and pressures ranging from 12 to 30 MPa. The mole fraction solubility of favipiravir was in the range of 3.0 × 10 -6 to 9.05 × 10 -4 . The solubility data were correlated with three types of methods including; (a) density-based models (Chrastil, Garlapati and Madras, Sparks et al., Sodeifian et al., K-J and Keshmiri et al.), (b) Equations of states SRK with quadratic mixing rules) and (c) expanded liquid theory (modified Wilson model). According to the results, modified Wilson and K-J models are generally capable of providing good correlation of solubility. Finally, the approximate values of total ( Δ H total ), vaporization ( Δ H vap ), and solvation ( Δ H sol ) enthalpies were computed.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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