Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.

Autor: Shahbaba B; Data Science Institute, University of California, Irvine, CA, USA.; Department of Statistics, University of California, Irvine, CA, USA.; Department of Computer Science, University of California, Irvine, CA, USA., Li L; Department of Statistics, University of California, Irvine, CA, USA.; Department of Computer Science, University of California, Irvine, CA, USA., Agostinelli F; Department of Statistics, University of California, Irvine, CA, USA.; Department of Computer Science, University of California, Irvine, CA, USA.; Artificial Intelligence Institute, University of South Carolina, Columbia, SC, USA., Saraf M; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Cooper KW; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Haghverdian D; Department of Statistics, University of California, Irvine, CA, USA., Elias GA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Baldi P; Department of Statistics, University of California, Irvine, CA, USA.; Department of Computer Science, University of California, Irvine, CA, USA., Fortin NJ; Data Science Institute, University of California, Irvine, CA, USA. norbert.fortin@uci.edu.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA. norbert.fortin@uci.edu.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. norbert.fortin@uci.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Feb 08; Vol. 13 (1), pp. 787. Date of Electronic Publication: 2022 Feb 08.
DOI: 10.1038/s41467-022-28057-6
Abstrakt: The hippocampus is critical to the temporal organization of our experiences. Although this fundamental capacity is conserved across modalities and species, its underlying neuronal mechanisms remain unclear. Here we recorded hippocampal activity as rats remembered an extended sequence of nonspatial events unfolding over several seconds, as in daily life episodes in humans. We then developed statistical machine learning methods to analyze the ensemble activity and discovered forms of sequential organization and coding important for order memory judgments. Specifically, we found that hippocampal ensembles provide significant temporal coding throughout nonspatial event sequences, differentiate distinct types of task-critical information sequentially within events, and exhibit theta-associated reactivation of the sequential relationships among events. We also demonstrate that nonspatial event representations are sequentially organized within individual theta cycles and precess across successive cycles. These findings suggest a fundamental function of the hippocampal network is to encode, preserve, and predict the sequential order of experiences.
(© 2022. The Author(s).)
Databáze: MEDLINE
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