Long-term clinical outcomes of patients with nonsignificant transplanted renal artery stenosis.

Autor: Barteczko MLM; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil. manoelacsfuk@gmail.com., Orellana HC; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Santos GRF; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Galhardo A; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Kanhouche G; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Faccinetto ACB; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Júnior HT; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil.; Division of Nephrology, Hospital Do Rim E Hipertensao, UNIFESP, São Paulo/SP, Brazil., Pestana JOM; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil.; Division of Nephrology, Hospital Do Rim E Hipertensao, UNIFESP, São Paulo/SP, Brazil., de Paola ÂAV; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil., Barbosa AHP; Department of Medicine, Cardiology Discipline, Federal University of Sao Paulo-UNIFESP, Sao Paulo Hospital, R. Napoleão de Barros, 715 - Vila Clementino, Sao Paulo/SP, 04024-002, Brazil.
Jazyk: angličtina
Zdroj: BMC nephrology [BMC Nephrol] 2022 Feb 08; Vol. 23 (1), pp. 61. Date of Electronic Publication: 2022 Feb 08.
DOI: 10.1186/s12882-022-02691-0
Abstrakt: Background: Transplant renal artery stenosis (TRAS) is the main vascular complication of kidney transplantation. For research and treatment purposes, several authors consider critical renal artery stenosis to be greater than 50%, and percutaneous intervention is indicated in this scenario. However, there are no reports in the current literature on the evolution of patients with less than 50% stenosis.
Method: This retrospective study included data from all patients who underwent kidney transplantation and were suspected of having TRAS after transplantation with stenosis under 50% independent of age and were referred for angiography at a single centre between January 2007 and December 2014.
Results: During this period, 6,829 kidney transplants were performed at Hospital do Rim, 313 of whom had a clinical suspicion of TRAS, and 54 of whom presented no significant stenosis. The average age was 35.93 years old, the predominant sex was male, and most individuals (94.4%) underwent dialysis before transplantation. In most cases in this group, transplants occurred from a deceased donor (66.7%). The time between transplantation and angiography was less than one year in 79.6% of patients, and all presented nonsignificant TRAS. Creatinine levels, systolic blood pressure, diastolic blood pressure and glomerular filtration rate improved over the long term. The outcomes found were death and allograft loss.
Conclusion: Age, sex and ethnic group of patients were factors that did not interfere with the frequency of renal artery stenosis. The outcomes showed that in the long term, most patients evolve well and have improved quality of life and kidney function, although there are cases of death and kidney loss.
(© 2022. The Author(s).)
Databáze: MEDLINE
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