A Simple and Efficient Embolization-Combined Therapy for Solid Tumors by Smart Poly(amino acid)s Nanocomposites.

Autor: Lu D; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China., Yu L; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China., Chen Z; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China., Chen M; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China., Lei Z; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China., Guo H; Institute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China., Wang X; Institute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China., Zhang Y; Institute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China., Xu T; Southeast University Zhongda Hospital, Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, School of Medicine, Southeast University, Nanjing 210009, China., Wang H; Gansu Provincial Hospital, Lanzhou 730000, P. R. China., Zhou X; Gansu Provincial Hospital, Lanzhou 730000, P. R. China., Ju S; Southeast University Zhongda Hospital, Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, School of Medicine, Southeast University, Nanjing 210009, China., Teng G; Southeast University Zhongda Hospital, Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, School of Medicine, Southeast University, Nanjing 210009, China.
Jazyk: angličtina
Zdroj: ACS applied bio materials [ACS Appl Bio Mater] 2022 Feb 21; Vol. 5 (2), pp. 661-674. Date of Electronic Publication: 2022 Feb 09.
DOI: 10.1021/acsabm.1c01106
Abstrakt: Interventional embolization and minimally invasive thermal ablation are common clinical methods for treatment of unresectable solid tumors, but they both have many insurmountable disadvantages. Inspired by pH-responsive drug delivery systems, we report the tumor microenvironment-gelled nanocomposites with poly[(l-glutamic acid- ran -l-tyrosine)- b -l-threonine- b -l-cysteine]s (PGTTCs) coating nanoparticles (NPs, Au or Fe 3 O 4 ) for noninterventional targeted embolization combined with noninvasive thermal ablation therapy of solid tumors by intravenous injection without catheter use. The results of the animal trial in vivo with tumor-bearing mice and rabbits showed superior targeted embolization and therapy and fluorescence/single-photon emission computed tomography/magnetic resonance multimodal imaging effects. Tumors treated with NPs@PGTTCs were shrunken and necrotized within 30 days, the long-term survival rate was more than 80%, and the same effects can be achieved within 15 days when combined with thermal ablation. The method is so simple and efficient for many hard-to-treat tumors within an acidic microenvironment, which is not only a great improvement and innovation in tumor theranostics but also an important development in nanomedicine.
Databáze: MEDLINE
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