Antibiotic Prophylaxis and Incidence of Infection with External Ventricular Drains and Intra-Cranial Pressure Monitors.

Autor:	Walton MN; Department of Pharmacy, University of Tennessee Medical Center, Knoxville, Tennessee, USA., Hamilton LA; Department of Pharmacy, University of Tennessee Medical Center, Knoxville, Tennessee, USA.; University of Tennessee Health Science Center College of Pharmacy, Knoxville, Tennessee, USA., Kennedy SJ; Department of Pharmacy, University of Tennessee Medical Center, Knoxville, Tennessee, USA., Veve MP; Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA., Rowe AS; Department of Pharmacy, University of Tennessee Medical Center, Knoxville, Tennessee, USA.; University of Tennessee Health Science Center College of Pharmacy, Knoxville, Tennessee, USA.
Jazyk:	angličtina
Zdroj:	Surgical infections [Surg Infect (Larchmt)] 2022 Apr; Vol. 23 (3), pp. 262-269. Date of Electronic Publication: 2022 Feb 08.
DOI:	10.1089/sur.2021.310
Abstrakt:	Objectives: Guidelines do not recommend extended antibiotic prophylaxis for external ventricular drains (EVD) or intra-cranial pressure (ICP) monitors. The study objective was to determine if infection rates are different for patients receiving antibiotic prophylaxis for EVD or ICP monitors. Patients and Methods: This single-center retrospective cohort reviewed intensive care unit patients who had an EVD or ICP monitor placed. Patients receiving antibiotic prophylaxis were compared with those who did not receive prophylaxis. The primary end point was incidence of central nervous system (CNS) infection. Results: Overall, 228 patients were included, 120 of whom received prophylaxis and 108 who did not receive prophylaxis. The primary end point of CNS infection was not different between groups (18 [17%] vs. 23 [19%]; p = 0.6236). Conclusions: Antibiotic prophylaxis was not associated with a decreased incidence of CNS infection in patients with EVD or ICP monitors. Evaluation of antibiotic use in this patient population is warranted to prevent resistance and adverse drug effects.
Databáze:	MEDLINE
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