Integrative Multiomics Evaluation of IIDH1 Metabolic Enzyme as a Candidate Oncogene That is Correlated with Poor Prognosis and Immune Infiltration in Prostate Adenocarcinoma.

Autor: Wen CY; Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan., Tsui KH; Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.; Institute of Biopharmaceutical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan., Chang CH; Department of Traditional Chinese Medicine, Tainan Municipal Hospital, Tainan 701, Taiwan., Chiu YH; Department of Microbiology, Soochow University, Taipei 111, Taiwan., Lin SA; Department of Nursing, National Yang Ming Chiao Tung University Hospital, Taipei 112, Taiwan.; Nursing School of National Yang Ming Chiao Tung University, Yilan 260, Taiwan., Chu CY; Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan., Li CJ; Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.; Institute of Biopharmaceutical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Jazyk: angličtina
Zdroj: Journal of oncology [J Oncol] 2022 Jan 29; Vol. 2022, pp. 9854788. Date of Electronic Publication: 2022 Jan 29 (Print Publication: 2022).
DOI: 10.1155/2022/9854788
Abstrakt: Mutations in the isocitrate dehydrogenase gene (IDH1) are involved in the progression of tumors. Although IDH1 has a role in various tumors, its clinical relevance and its expression in response to the immune response have not been investigated in prostate adenocarcinoma (PRAD). In the present study, we investigated the utility of IDH1 as a prognostic biomarker for PRAD by analyzing IDH1 mRNA expression and its association with patient survival and immune cell infiltration. IDH1 mRNA expression was significantly higher in PRAD tissue than in normal tissue, and Kaplan-Meier survival analysis showed that IDH1 expression was significantly associated with poor prognosis in PRAD patients. To elucidate the mechanisms involved, the correlation between IDH1 expression and the level of immune cell infiltration, in particular of immunosuppressive cells such as CD8+ T-cells, CD4+ T-cells, and macrophages, was further analyzed by single-cell RNA sequencing. We also screened a pharmacogenetic database for IDH1-specific drugs that inhibited high expression in PRAD. In the present study, we used a combination of databases to identify a significant correlation between IDH1 expression and cellular infiltration and to explain the mechanism by which IDH1 confers poor prognosis in PRAD, thus demonstrating the relevance of IDH1 expression as a prognostic biomarker with clinical utility in PRAD patients.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflicts of interest.
(Copyright © 2022 Chen-Yueh Wen et al.)
Databáze: MEDLINE
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