Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature.

Autor: Patanè L; Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address: lpatane@asst-pg23.it., Cadamuro M; Department of Molecular Medicine, University of Padua, Padua, Italy., Massazza G; Department of Pathology, ASST Papa Giovanni XXIII, Bergamo, Italy., Pirola S; Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII, Bergamo, Italy., Stagnati V; Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII, Bergamo, Italy., Comerio C; Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII, Bergamo, Italy., Carnelli M; Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII, Bergamo, Italy., Arosio M; Microbiology and Virology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Biobank Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Callegaro AP; Microbiology and Virology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Biobank Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Tebaldi P; Department of Pathology, ASST Papa Giovanni XXIII, Bergamo, Italy., Rigoli E; Department of Pathology, ASST Papa Giovanni XXIII, Bergamo, Italy., Gianatti A; Department of Pathology, ASST Papa Giovanni XXIII, Bergamo, Italy., Morotti D; Department of Pathology, ASST Papa Giovanni XXIII, Bergamo, Italy.
Jazyk: angličtina
Zdroj: American journal of obstetrics & gynecology MFM [Am J Obstet Gynecol MFM] 2022 May; Vol. 4 (3), pp. 100589. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1016/j.ajogmf.2022.100589
Abstrakt: Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and fetal markers of infection were detected, despite the absence of respiratory syndrome. The patient developed clinical chorioamnionitis and spontaneously delivered 2 stillborn infants. Placental histology and immunohistochemistry demonstrated SARS-CoV-2 infection mostly within the syncytiotrophoblast, and fetal autopsy showed the development of interstitial pneumonia. Our findings demonstrated that in utero vertical transmission is possible in asymptomatic pregnant women with SARS-CoV-2 infection and that infection can lead to severe morbidity in the second trimester of pregnancy.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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