Stem Cell Therapies for Restorative Treatments of Central Nervous System Ischemia-Reperfusion Injury.

Autor: Su QS; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510080, Guangdong, China., Zhuang DL; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China.; College of Medicine, Shantou University, Shantou, 515063, Guangdong, China., Nasser MI; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China., Sai X; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.; Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao City, 028000, Inner Mongolia, China., Deng G; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China.; School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China., Li G; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China. lige5@mail.sysu.edu.cn.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510080, Guangdong, China. lige5@mail.sysu.edu.cn., Zhu P; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, Guangdong, China. tanganqier@163.com.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510080, Guangdong, China. tanganqier@163.com.; College of Medicine, Shantou University, Shantou, 515063, Guangdong, China. tanganqier@163.com.; Guangdong Provincial Key Laboratory of Structural Heart Disease, Guangzhou, 510100, Guangdong, China. tanganqier@163.com.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China. tanganqier@163.com.; Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao City, 028000, Inner Mongolia, China. tanganqier@163.com.
Jazyk: angličtina
Zdroj: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Mar; Vol. 43 (2), pp. 491-510. Date of Electronic Publication: 2022 Feb 07.
DOI: 10.1007/s10571-022-01204-9
Abstrakt: Ischemic damage to the central nervous system (CNS) is a catastrophic postoperative complication of aortic occlusion subsequent to cardiovascular surgery that can cause brain impairment and sometimes even paraplegia. Over recent years, numerous studies have investigated techniques for protecting and revascularizing the nervous system during intraoperative ischemia; however, owing to a lack of knowledge of the physiological distinctions between the brain and spinal cord, as well as the limited availability of testing techniques and treatments for ischemia-reperfusion injury, the cause of brain and spinal cord ischemia-reperfusion injury remains poorly understood, and no adequate response steps are currently available in the clinic. Given the limited ability of the CNS to repair itself, it is of great clinical value to make full use of the proliferative and differentiation potential of stem cells to repair nerves in degenerated and necrotic regions by stem cell transplantation or mobilization, thereby introducing a novel concept for the treatment of severe CNS ischemia-reperfusion injury. This review summarizes the most recent advances in stem cell therapy for ischemia-reperfusion injury in the brain and spinal cord, aiming to advance basic research and the clinical use of stem cell therapy as a promising treatment for this condition.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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