HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis.
| Autor: | Albakova Z; Department of Biology, Lomonosov Moscow State University, Moscow, Russia., Mangasarova Y; National Research Center for Hematology, Moscow, Russia., Albakov A; Department of Innovation, Almaty, Kazakhstan., Gorenkova L; National Research Center for Hematology, Moscow, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in oncology [Front Oncol] 2022 Jan 21; Vol. 12, pp. 829520. Date of Electronic Publication: 2022 Jan 21 (Print Publication: 2022). |
| DOI: | 10.3389/fonc.2022.829520 |
| Abstrakt: | HSP70 and HSP90 are two powerful chaperone machineries involved in survival and proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 perform specific functions. Concurrently, HSP70 and HSP90 homologs may also translocate from their primary site under various stress conditions. Herein, we address the current literature on the role of HSP70 and HSP90 chaperone networks in cancer. The goal is to provide a comprehensive review on the functions of cytosolic, mitochondrial and endoplasmic reticulum HSP70 and HSP90 homologs in cancer. Given that high expression of HSP70 and HSP90 enhances tumor development and associates with tumor aggressiveness, further understanding of HSP70 and HSP90 chaperone networks may provide clues for the discoveries of novel anti-cancer therapies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Albakova, Mangasarova, Albakov and Gorenkova.) |
| Databáze: | MEDLINE |
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