Lignans and sesquiterpenes from Schisandra tomentella A. C. Smith.

Autor: Wu CM; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China., Chu W; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China., Chen YL; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China., Liang DE; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China., Qiu FJ; Zhejiang Xinguang Pharmaceutical Limited Liability Company, Shaoxing 312400, PR China., Zhan ZJ; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China., Ma LF; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China; Zhejiang Xinguang Pharmaceutical Limited Liability Company, Shaoxing 312400, PR China. Electronic address: maliefeng@zjut.edu.cn.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2022 Apr; Vol. 158, pp. 105142. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1016/j.fitote.2022.105142
Abstrakt: This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1-2), and two new sesquiterpenoids, tomentaschinnes A-B (3-4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M 2 (7) could promote the efficacy of adriamycin against MCF-7/ADR.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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