Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations.

Autor: Diaconu C; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Lee AJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Onomichi K; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., De Jager RL; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Riley C; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Levine L; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Vargas W; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Shelter K; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., De Jager PL; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Farber RS; Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA. Electronic address: rebeccastraus@msn.com.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2022 Mar; Vol. 59, pp. 103508. Date of Electronic Publication: 2022 Jan 10.
DOI: 10.1016/j.msard.2022.103508
Abstrakt: It has been hypothesized that multiple sclerosis (MS) has hormonal influences, and testosterone may have anti-inflammatory functions in this context. Given prior reports of lower testosterone levels in men with MS in archival serum samples, we evaluated the prevalence of hypogonadism in the clinical setting and its association with disability in men with MS. Subjects were screened for symptoms of hypogonadism using a clinical instrument, and those with positive screens had total and free morning testosterone levels checked. Of the 64 subjects who were screened, 50 (78%) had positive results, and 46 (92%) had morning testosterone levels checked. Among the latter, 5 were found to have testosterone levels below lower limit of normal. Other than the expected inverse relation with BMI, testosterone did not correlate with demographic or disease related factors. Baseline testosterone did not predict risk of EDSS or T25-FW progression or future MRI activity.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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