Real-world data from selective laser trabeculoplasty in Brazil.

Autor: Abe RY; Hospital Oftalmológico de Brasília, SGAS 607 Avenida L2 Sul, Distrito Federal, Brasília, ZIP Code 70200670, Brazil. ricardoabe85@yahoo.com.br.; Department of Ophthalmology - University of Campinas, Campinas, Brazil. ricardoabe85@yahoo.com.br., Maestrini HA; Oculare, Hospital de Olhos, Belo Horizonte, Minas Gerais, Brazil., Guedes GB; Hospital de Olhos do Paraná, Curitiba, Paraná, Brazil., Nascimento MM; Clínica Glaukos, São José do Rio Preto, São Paulo, Brazil., Iguma CI; Hospital Oftalmológico de Brasília, SGAS 607 Avenida L2 Sul, Distrito Federal, Brasília, ZIP Code 70200670, Brazil., de Miranda Santos HD; Oculare, Hospital de Olhos, Belo Horizonte, Minas Gerais, Brazil., Nasr MG; Hospital de Olhos do Paraná, Curitiba, Paraná, Brazil., Lucena-Junior RP; Hospital Medicina Dos Olhos, Osasco, São Paulo, Brazil., Prata TS; Hospital Medicina Dos Olhos, Osasco, São Paulo, Brazil.; Departamento de Oftalmologia, UNIFESP/EPM, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Feb 04; Vol. 12 (1), pp. 1923. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1038/s41598-022-05699-6
Abstrakt: Evaluate real-world data of outcomes from selective laser trabeculoplasty (SLT) performed in different regions of Brazil and investigate potential predictors of success associated with treatment. Multicenter retrospective case series with patients who underwent a primary SLT procedure. A total of 835 eyes from 835 patients were included. The mean follow-up was 916.8 ± 563.0 days. The mean age was 64.5 ± 14.9 years and 56.6% were women. We observed an intraocular pressure reduction comparing baseline to post-SLT measurements (18.4 ± 3.8 mmHg versus 14.8 ± 3.5 mmHg; P < 0.001) and mean number of glaucoma medications (1.8 ± 1.3 versus 1.4 ± 1.4; P < 0.001). We observed visual acuity loss over time (0.1 ± 0.3 versus 0.2 ± 0.3 logMAR, baseline and post-SLT, respectively, P = 0.009) and decrease in visual field mean deviation values (- 5.4 ± 5.9 versus - 5.7 ± 6.0 dB; P = 0.054) The Kaplan-Meier survival analysis showed an estimated probability of treatment success of 88% at 12 months, declining to 70% at 24 months and 54% at 36 months post-SLT. In the multivariable model, we found that a denser angle pigmentation (HR 0.69; 95% CI 0.57-0.85, P = 0.001) and corticosteroid treatment following SLT (HR 0.59; 95% CI 0.39-0.91, P = 0.018) were significantly associated with a lower risk for failure. Primary SLT achieved relatively high success rates without sight-threating complications in this real-world study with a large sample of Brazilian patients. These findings corroborate previous studies regarding SLT outcomes and may help clinicians to identify the best candidates for laser treatment.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje