The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.

Autor: Kubrak O; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Koyama T; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Ahrentløv N; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Jensen L; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Malita A; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Naseem MT; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Lassen M; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Nagy S; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Texada MJ; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Halberg KV; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark., Rewitz K; Department of Biology, University of Copenhagen, 2100, Copenhagen O, Denmark. Kim.Rewitz@bio.ku.dk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Feb 04; Vol. 13 (1), pp. 692. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1038/s41467-022-28268-x
Abstrakt: The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs to coordinate systemic energy balance. However, the gut-derived hormones affecting metabolic and behavioral responses are poorly defined. Here we show that the endocrine cells of the Drosophila gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a Drosophila somatostatin homolog. Gut-derived allatostatin C induces secretion of glucagon-like adipokinetic hormone to coordinate food intake and energy mobilization. Loss of gut Allatostatin C or its receptor in the adipokinetic-hormone-producing cells impairs lipid and sugar mobilization during fasting, leading to hypoglycemia. Our findings illustrate a nutrient-responsive endocrine mechanism that maintains energy homeostasis under nutrient-stress conditions, a function that is essential to health and whose failure can lead to metabolic disorders.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz: