US Postarrival Evaluation of Immigrant and Refugee Children with Latent Tuberculosis Infection Diagnosed Overseas, 2007-2019.

Autor: Wang Z; Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: zwang@cdc.gov., Posey DL; Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA., Brostrom RJ; Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA., Morris SB; Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA., Marano N; Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA., Phares CR; Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2022 Jun; Vol. 245, pp. 149-157.e1. Date of Electronic Publication: 2022 Feb 01.
DOI: 10.1016/j.jpeds.2022.01.049
Abstrakt: Objective: To assess outcomes from the US postarrival evaluation of newly arrived immigrant and refugee children aged 2-14 years who were diagnosed with latent tuberculosis infection (LTBI) during a required overseas medical examination.
Study Design: We compared overseas and US interferon-γ release assay (IGRA)/tuberculin skin test (TST) results and LTBI diagnosis; assessed postarrival LTBI treatment initiation and completion; and evaluated the impact of switching from TST to IGRA to detect Mycobacterium tuberculosis infection overseas.
Results: In total, 73 014 children were diagnosed with LTBI overseas and arrived in the US during 2007-2019. In the US, 45 939 (62.9%) completed, and 1985 (2.7%) initiated but did not complete a postarrival evaluation. Among these 47 924 children, 30 360 (63.4%) were retested for M tuberculosis infection. For 17 996 children with a positive overseas TST, 73.8% were negative when retested by IGRA. For 1051 children with a positive overseas IGRA, 58.0% were negative when retested by IGRA. Overall, among children who completed a postarrival evaluation, 18 544 (40.4%) were evaluated as having no evidence of TB infection, and 25 919 (56.4%) had their overseas LTBI diagnosis confirmed. Among the latter, 17 229 (66.5%) initiated and 9185 (35.4%) completed LTBI treatment.
Conclusions: Requiring IGRA testing overseas could more effectively identify children who will benefit from LTBI treatment. However, IGRA reversions may occur, highlighting the need for individualized assessment for risk of infection, progression, and poor outcome when making diagnostic and treatment decisions. Strategies are needed to increase the proportions receiving a postarrival evaluation and completing LTBI treatment.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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