Emerging Bioelectronic Strategies for Cardiovascular Tissue Engineering and Implantation.

Autor: Cox-Pridmore DM; National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom.; Advanced Technology Institute, Department of Electrical and Electronic Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom., Castro FA; National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom.; Advanced Technology Institute, Department of Electrical and Electronic Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom., Silva SRP; Advanced Technology Institute, Department of Electrical and Electronic Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom., Camelliti P; School of Biosciences and Medicine, University of Surrey, Guildford, Surrey, GU2 7XH, UK., Zhao Y; National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom.; Advanced Technology Institute, Department of Electrical and Electronic Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Apr; Vol. 18 (17), pp. e2105281. Date of Electronic Publication: 2022 Feb 04.
DOI: 10.1002/smll.202105281
Abstrakt: Heart diseases are currently the leading cause of death worldwide. The ability to create cardiovascular tissue has numerous applications in understanding tissue development, disease progression, pharmacological testing, bio-actuators, and transplantation; yet current cardiovascular tissue engineering (CTE) methods are limited. However, there have been emerging developments in the bioelectronics field, with the creation of biomimetic devices that can intimately interact with cardiac cells, provide monitoring capabilities, and regulate tissue formation. Combining bioelectronics with cardiac tissue engineering can overcome current limitations and produce physiologically relevant tissue that can be used in various areas of cardiovascular research and medicine. This review highlights the recent advances in cardiovascular-based bioelectronics. First, cardiac tissue engineering and the potential of bioelectronic therapies for cardiovascular diseases are discussed. Second, advantageous bioelectronic materials for CTE and implantation and their properties are reviewed. Third, several representative cardiovascular tissue-bioelectronic interface models and the beneficial functions that bioelectronics can demonstrate in in vitro and in vivo applications are explored. Finally, the prospects and remaining challenges for clinical application are discussed.
(© 2022 The Authors. Small published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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