Redo pelvic fracture urethral injury repair: The case for tadalafil.

Autor: Joshi DP; Kulkarni Reconstructive Urology Center, Pune, India., Desai D; Kulkarni Reconstructive Urology Center, Pune, India., Fuziwara S; Kulkarni Reconstructive Urology Center, Pune, India., Raveenthiran S; Kulkarni Reconstructive Urology Center, Pune, India., Nafea M; Kulkarni Reconstructive Urology Center, Pune, India., Kulkarni SB; Kulkarni Reconstructive Urology Center, Pune, India.
Jazyk: angličtina
Zdroj: Turkish journal of urology [Turk J Urol] 2021 Jul; Vol. 47 (4), pp. 319-324.
DOI: 10.5152/tud.2021.21065
Abstrakt: Objective: To define the role of tadalafil in improving outcomes of redo urethroplasty for pelvic fracture urethral injury (PFUI). PFUI is common in developing countries, invariably as a result of road traffic trauma. Repair is complex, and redo cases are even more challenging.
Material and Methods: This was a longitudinal prospective nonrandomized study between 2017 and 2019. Men undergoing redo-urethroplasty were nonrandomized into two groups. Group 1 received tadalafil 5 mg the next day after surgery and continued for 3 months, and group 2 did not receive tadalafil. Inclusion criteria were patients undergoing redo-urethroplasty willing to trial low-dose tadalafil post-operatively. Exclusion criteria were <18 years, females, primary cases, and complex cases such as recto-urethral fistula. Average follow-up was 19.5 months.
Results: Sixty patients were enrolled (29 in group 1 and 31 in group 2). Mean age was 31 years. These patients had 1-3 prior failed urethroplasties. Most required step 3 anastomotic urethroplasty (68.3%). Success was defined as absence of symptoms and no need for surgical intervention. Failure was defined as redo urethroplasty or >1 endoscopic intervention. Primary success was 83.3%. Success with tadalafil was 96.6%, compared to 71.0% in the non-Tadalafil group (P ¼ .0008). Only one patient on tadalafil failed, compared with nine in the non-tadalafil group. Secondary success rate was defined as the need for a single subsequent endoscopic intervention and was 93.3%.
Conclusion: In our series, there was improved outcome with using tadalafil in patients having redo urethroplasty for PFUI. Further trials should be done to evaluate the use in all PFUI cases.
Databáze: MEDLINE
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