Anti-SARS-CoV-2 Antibody Screening in Healthcare Workers and Its Correlation with Clinical Presentation in Tertiary Care Hospital, Kathmandu, Nepal, from November 2020 to January 2021.

Autor: Aryal S; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Pandit S; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Pokhrel S; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Chhusyabaga M; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Bista P; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Bhatt MP; Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal., Subedi DD; Department of General Medicine, Manmohan Memorial Medical College and Teaching Hospital, Kathmandu, Nepal., Rijal BP; Department of Clinical Microbiology, Manmohan Memorial Medical College and Teaching Hospital, Kathmandu, Nepal.
Jazyk: angličtina
Zdroj: Interdisciplinary perspectives on infectious diseases [Interdiscip Perspect Infect Dis] 2022 Feb 01; Vol. 2022, pp. 8515051. Date of Electronic Publication: 2022 Feb 01 (Print Publication: 2022).
DOI: 10.1155/2022/8515051
Abstrakt: Background: Antibody titer and the life span of antibodies against SARS-CoV-2 have been found to be associated with the clinical presentation in individuals. The extent of exposure of healthcare workers and the general public to SARS-CoV-2 needs to be assessed to monitor the COVID-19 pandemic. Thus, this study is an attempt in assessing the anti-SARS-CoV-2 antibody in health care workers.
Methods: This laboratory-based cross-sectional study was performed in Manmohan Memorial Medical College and Teaching Hospital, Kathmandu from November 2020 to January 2021. A total of 185 HCWs were enrolled in this study. Their serum samples were screened for anti-SARS-CoV-2 antibodies, and a structured questionnaire was administered to collect further information. Anti-SARS-CoV-2 antibody screening was performed using lateral flow immunoassay. The data were analyzed using SPSS version 20.
Results: Among 185 HCWs that participated in the study, 41 (22.2%) tested positive for the anti-SARS-CoV-2 antibody. Of these 41 HCWs, 37 tested positive for IgG only and 4 of them tested positive for both IgM and IgG antibodies. The presence of the previous history of SARS-CoV-2 infection ( p < 0.001), the presence of flu-like symptoms within the last 6 months ( p < 0.001), and the presence of positive contact history ( p =0.002) were statistically significant with the presence of the antibody among HCWs.
Conclusion: Healthcare workers carry a high burden of SARS-CoV-2 infection and are at risk of acquiring infection from their workplace. Anti-SARS-CoV-2 antibody screening among healthcare workers is highly recommended in multiple healthcare settings as it can help in monitoring transmission dynamics and evaluation of infection control policies.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Suraj Aryal et al.)
Databáze: MEDLINE
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