Evaluation of Predisposing Metabolic Risk Factors for Portopulmonary Hypertension in Patients with NASH Cirrhosis.

Autor:	Türker F; University of Health Sciences, Haseki Health Training and Research Hospital, Internal Medicine Clinic, İstanbul, Turkey., Sahın T; Demiroglu Bilim University, Florence Nightingale Hospital Internal Medicine Clinic, İstanbl, Turkey., Oral A; Demiroglu Bilim University, Florence Nightingale Hospital Internal Medicine Clinic, İstanbl, Turkey., Koçak E; Istinye University, Liv Hospital Vadi Istanbul, Gastroenterology, İstanbul, Turkey., Çavuşoğlu Türker B; University of Health Sciences, Taksim Health Training and Research Hospital, Internal Medicine Clinic, İstanbul, Turkey., Niğdelioğlu A; Demiroglu Bilim University, Florence Nightingale Hospital Internal Medicine Clinic, İstanbl, Turkey., Esra Ataoğlu H; University of Health Sciences, Haseki Health Training and Research Hospital, Internal Medicine Clinic, İstanbul, Turkey.
Jazyk:	angličtina
Zdroj:	International journal of general medicine [Int J Gen Med] 2022 Jan 25; Vol. 15, pp. 859-865. Date of Electronic Publication: 2022 Jan 25 (Print Publication: 2022).
DOI:	10.2147/IJGM.S339474
Abstrakt:	Purpose: Metabolic parameters are important for the development of portopulmonary hypertension (PoPH) during nonalcoholic steatohepatitis (NASH)-associated cirrhosis. This study evaluated patients with NASH-associated cirrhosis to determine metabolic risk factors for portopulmonary hypertension. Patients and Methods: Data on 171 patients (120 men and 51 women) with NASH-associated cirrhosis who were seen in Florence Nightingale Hospital's gastroenterology Clinic from 2009 to 2018 was obtained from the Hospital database. A pulmonary artery systolic pressure >35 mmHg was defined as PH (pulmonary hypertension) according to standard transthoracic echocardiography. Portal hypertension was diagnosed from clinical symptoms and dilated portal veins shown by abdominal ultrasound or computed tomography (CT). Pulmonary patients with portal hypertension were diagnosed with portopulmonary hypertension (PoPH). Results: A total of 171 patients with NASH-associated cirrhosis were included in this study. Of these, 43 patients had PoPH. These patients had increased TSH (p=0.004), bilirubin (p=0.023) and triglyceride (p=0.048) levels, higher MELD scores (p=0.018) and decreased hemoglobin (p=0.05). MELD score and hemoglobin, total bilirubin, TSH, and triglyceride levels were all included in a multivariate logistic regression model and TSH levels were independently associated with increased risk of PoPH. Conclusion: Increased TSH is an independent risk factor for PoPH. Competing Interests: The author reports no conflicts of interest in this work. (© 2022 Türker et al.)
Databáze:	MEDLINE
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