Multiple expansions of globally uncommon SARS-CoV-2 lineages in Nigeria.

Autor: Ozer EA; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, USA., Simons LM; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, USA., Adewumi OM; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria., Fowotade AA; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Biorepository and Clinical Virology Laboratory, College of Medicine, University College Hospital, University of Ibadan, Ibadan, Nigeria., Omoruyi EC; Biorepository and Clinical Virology Laboratory, College of Medicine, University College Hospital, University of Ibadan, Ibadan, Nigeria., Adeniji JA; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria., Olayinka OA; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria., Dean TJ; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, USA., Zayas J; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Bhimalli PP; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Ash MK; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Maiga AI; University Clinical Research Center (UCRC), University of Sciences, Techniques et Technologies of Bamako (USTTB), Bamako, Mali., Somboro AM; University Clinical Research Center (UCRC), University of Sciences, Techniques et Technologies of Bamako (USTTB), Bamako, Mali.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Maiga M; University Clinical Research Center (UCRC), University of Sciences, Techniques et Technologies of Bamako (USTTB), Bamako, Mali.; Biomedical Engineering and Preventive Medicine Department, Northwestern University, Evanston, IL, USA., Godzik A; Biosciences Division, University of California Riverside School of Medicine, Riverside, CA, USA., Schneider JR; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Mamede JI; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Taiwo BO; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hultquist JF; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. judd.hultquist@northwestern.edu.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, USA. judd.hultquist@northwestern.edu., Lorenzo-Redondo R; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ramon.lorenzo@northwestern.edu.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, USA. ramon.lorenzo@northwestern.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Feb 03; Vol. 13 (1), pp. 688. Date of Electronic Publication: 2022 Feb 03.
DOI: 10.1038/s41467-022-28317-5
Abstrakt: Disparities in SARS-CoV-2 genomic surveillance have limited our understanding of the viral population dynamics and may delay identification of globally important variants. Despite being the most populated country in Africa, Nigeria has remained critically under sampled. Here, we report sequences from 378 SARS-CoV-2 isolates collected in Oyo State, Nigeria between July 2020 and August 2021. In early 2021, most isolates belonged to the Alpha "variant of concern" (VOC) or the Eta lineage. Eta outcompeted Alpha in Nigeria and across West Africa, persisting in the region even after expansion of an otherwise rare Delta sub-lineage. Spike protein from the Eta variant conferred increased infectivity and decreased neutralization by convalescent sera in vitro. Phylodynamic reconstructions suggest that Eta originated in West Africa before spreading globally and represented a VOC in early 2021. These results demonstrate a distinct distribution of SARS-CoV-2 lineages in Nigeria, and emphasize the need for improved genomic surveillance worldwide.
(© 2022. The Author(s).)
Databáze: MEDLINE
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