Clinical Utility of 18 F-FDG PET/CT in the Work-up of Children with Uveitis.

Autor: Bazewicz M; Ophthalmology, CHU Saint Pierre and CHU Brugmann, Brussels, Belgium., Makhoul D; Ophthalmology, CHU Saint Pierre, Brussels, Belgium., Goffin L; Pediatry, Queen Fabiola Children's University Hospital, Brussels, Belgium., El Mouden J; Ophthalmology, CHU Brugmann, Brussels, Belgium., Judice M Relvas L; Ophthalmology, CHU Saint Pierre, Brussels, Belgium., Caspers L; Ophthalmology, CHU Saint Pierre, Brussels, Belgium., Draganova D; Ophthalmology, CHU Saint Pierre and CHU Brugmann, Brussels, Belgium., Postelmans L; Ophthalmology, CHU Brugmann, Brussels, Belgium., Garcia C; Nuclear Medicine, CHU Saint Pierre, Université Libre De Bruxelles, Brussels, Belgium., Willermain F; Ophthalmology, CHU Saint-Pierre and CHU Brugmann, Université Libre De Bruxelles, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 Jan; Vol. 31 (1), pp. 77-86. Date of Electronic Publication: 2022 Feb 03.
DOI: 10.1080/09273948.2021.1985522
Abstrakt: Purpose: To evaluate 18 F-fluorodeoxyglucose Positron Emission Tomography/ultra low dose Computed Tomography ( 18 F-FDG PET/ ULD CT) in the work-up of pediatric uveitis.
Methods: Retrospective study of 12 children followed for uveitis who underwent whole body 18 F-FDG PET/ULD CT between 2011 and 2019.
Results: The average age of the patients was 11 years. A total of 100% of patients presented with bilateral uveitis, 50% had panuveitis and 92% had various choroidal involvement. Relevant information for diagnosis was provided in four patients. 5/12 had an abnormal 18F-FDG uptake. Of these, three patients had pathognomonic images of active granulomatous diseases. Three patients underwent PET CT-guided biopsies of which two were positive for sarcoidosis.
Conclusion: 18 F-FDG PET/CT provided important information for final diagnosis in approximately 30% (4/12) of pediatric patients with bilateral uveitis. Whole body FDG PET/ULD CT can contribute to the final diagnosis thanks to pathognomonic image of active granulomatous disease and/or by indicating metabolically active site of biopsy that would not be visualized in thorax CT.
Databáze: MEDLINE
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