| Autor: |
Tian MR; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Du K; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China., Zhi YL; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Xue GM; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Zhao ZZ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Si YY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Chen H; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Sun YJ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Feng WS; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China., Ma JL; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. |
| Abstrakt: |
One new 6a,11a-dehydropterocarpan derivative, 6- O -methyl-anhydrotuberosin ( 1 ), one new 6a-hydroxypterocarpan, (6a R ,11a R ,11b R )-hydroxytuberosone ( 7 ), and seven known compounds including two 6a,11a-dehydropterocarpans ( 2 and 4 ), two coumestans ( 3 and 5 ), one isoflavonoid ( 6 ) and two other phenolic compounds ( 8 and 9 ) were isolated from the roots of Pueraria lobata . The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1 D and 2DNMR, HRESIMS). Compounds 1, 2, 4 - 5 showed potent LSD1 inhibitory activities with IC 50 values ranging from 1.73 to 4.99 μM. Furthermore, compound 2 showed potent cytotoxicity against gastric cancer cell lines MGC-803 and BGC-823, and lung cancer cell lines H1299 and H460. |
