Cell-type-specific responses to associative learning in the primary motor cortex.

Autor:	Lee C; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada., Harkin EF; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada., Yin X; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada., Naud R; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.; Department of Physics, STEM Complex, University of Ottawa, Ottawa, Canada.; Brain and Mind Research Institute, University of Ottawa, Ottawa, Canada.; Center for Neural Dynamics, University of Ottawa, Ottawa, Canada., Chen S; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.; Brain and Mind Research Institute, University of Ottawa, Ottawa, Canada.; Center for Neural Dynamics, University of Ottawa, Ottawa, Canada.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2022 Feb 03; Vol. 11. Date of Electronic Publication: 2022 Feb 03.
DOI:	10.7554/eLife.72549
Abstrakt:	The primary motor cortex (M1) is known to be a critical site for movement initiation and motor learning. Surprisingly, it has also been shown to possess reward-related activity, presumably to facilitate reward-based learning of new movements. However, whether reward-related signals are represented among different cell types in M1, and whether their response properties change after cue-reward conditioning remains unclear. Here, we performed longitudinal in vivo two-photon Ca 2+ imaging to monitor the activity of different neuronal cell types in M1 while mice engaged in a classical conditioning task. Our results demonstrate that most of the major neuronal cell types in M1 showed robust but differential responses to both the conditioned cue stimulus (CS) and reward, and their response properties undergo cell-type-specific modifications after associative learning. PV-INs' responses became more reliable to the CS, while VIP-INs' responses became more reliable to reward. Pyramidal neurons only showed robust responses to novel reward, and they habituated to it after associative learning. Lastly, SOM-INs' responses emerged and became more reliable to both the CS and reward after conditioning. These observations suggest that cue- and reward-related signals are preferentially represented among different neuronal cell types in M1, and the distinct modifications they undergo during associative learning could be essential in triggering different aspects of local circuit reorganization in M1 during reward-based motor skill learning. Competing Interests: CL, EH, XY, RN, SC No competing interests declared (© 2022, Lee et al.)
Databáze:	MEDLINE
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