Detection, dietary exposure assessment and risk evaluation of quinolones and pyrrolizidine alkaloids in commercial honey from Brazil.

Autor: Bandini TB; Farmanguinhos - Departamento de Métodos Analíticos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Spisso BF; Laboratório de Resíduos de Medicamentos Veterinários Em Alimentos, Fundação Oswaldo Cruz - Instituto Nacional de Controle de Qualidade Em Saúde, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Food additives & contaminants. Part B, Surveillance [Food Addit Contam Part B Surveill] 2022 Jun; Vol. 15 (2), pp. 89-97. Date of Electronic Publication: 2022 Feb 03.
DOI: 10.1080/19393210.2022.2028310
Abstrakt: Pyrrolizidine alkaloids are secondary plant metabolites that have already been designated as a potential health risk due to their toxicity. Quinolones are antimicrobials related to bacterial resistance, one of the world's largest contemporary public health problems. This study searched for 22 pyrrolizidine alkaloids and 7 quinolones in honey available for sale in the state of Rio de Janeiro - Brazil - employing an analytical method based on LC-Q-TOF-HRMS. No quinolones were identified, while pyrrolizidine alkaloids were found in 39 out of 80 samples, mainly erucifoline (detected in 17% of the samples) and intermedine/lycopsamine (quantified in 27% of the samples). Considering the highest value found, 141.8 µg kg -1 for senecionine and a consumption of 20 g of honey per person per day, the dietary exposure reached 47.3 ng kg -1 , resulting in a MOE value of 5.010, that might lead to a risk for human health.
Databáze: MEDLINE
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