Effect of a Diet Supplemented with Sphingomyelin and Probiotics on Colon Cancer Development in Mice.

Autor: Marzo F; Laboratory of Animal Physiology and Nutrition, School of Agronomy, Universidad Pública de Navarra, Pamplona, Spain., Jauregui P; Laboratory of Animal Physiology and Nutrition, School of Agronomy, Universidad Pública de Navarra, Pamplona, Spain., Barrenetxe J; Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain., Martínez-Peñuela A; Laboratorio Martínez-Peñuela, Pamplona, Spain., Ibañez FC; Laboratory of Animal Physiology and Nutrition, School of Agronomy, Universidad Pública de Navarra, Pamplona, Spain., Milagro FI; Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain. fmilagro@unav.es.; Navarra Institute for Health Research (IdISNA), Pamplona, Spain. fmilagro@unav.es.; Centro de Investigación Biomédica en Red de La Fisiopatología de La Obesidad Y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. fmilagro@unav.es.
Jazyk: angličtina
Zdroj: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2022 Jun; Vol. 14 (3), pp. 407-414. Date of Electronic Publication: 2022 Feb 02.
DOI: 10.1007/s12602-022-09916-6
Abstrakt: Previous studies have reported that dietary sphingomyelin could inhibit early stages of colon cancer. Lactic acid-producing bacteria have also been associated with an amelioration of cancer symptoms. However, little is known about the potential beneficial effects of the combined administration of both sphingomyelin and lactic acid-producing bacteria. This article analyzes the effect of a diet supplemented with a combination of the probiotics Lacticaseibacillus casei and Bifidobacterium bifidum (10 8  CFU/ml) and sphingomyelin (0.05%) on mice with 1,2-dimethylhydrazine (DMH)-induced colon cancer. Thirty-six BALB/c mice were divided into 3 groups: one healthy group (group C) and two groups with DMH-induced cancer, one fed a standard diet (group D) and the other fed a diet supplemented with sphingomyelin and probiotics (DS). The number of aberrant crypt foci, marker of colon cancer development, was lower in the DS. The dietary supplementation with the synbiotic reversed the cancer-induced impairment of galactose uptake in enterocyte brush-border-membrane vesicles. These results confirm the beneficial effects of the synbiotic on the intestinal physiology of colon cancer mice and contribute to the understanding of the possible mechanisms involved.
(© 2022. The Author(s).)
Databáze: MEDLINE
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