Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats.

Autor: Al-Gabri N; Veterinary Department, Faculty of Agriculture and Veterinary Medicine, Thamar University, Dhamar, Yemen.; Laboratory of Salam Veterinary Group, Buraydah, Al-Qassim, Saudi Arabia., Elnagar GM; Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Saghir SAM; Department of Medical Analysis, Princess Aisha Bint Al Hussein College of Nursing and Medical Analysis, Al-Hussein Bin Talal University, Ma'an, Jordan., El-Shaibany A; Pharmacognosy Department, University of Sana'a, Pharmacy College, Yemen., Alnomasy SF; Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Al-Quwayiyah, Shaqra University, Al-Quwayiyah, Riyadh, Saudi Arabia., Althafar ZM; Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Al-Quwayiyah, Shaqra University, Al-Quwayiyah, Riyadh, Saudi Arabia., Elkomy NMIM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt., Elaasser MM; The Regional Center for Mycology and Biotechnology, Al-Azhar University, 11787 Nasr City, Cairo, Egypt., Abdoh MS; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia., Yosri M; The Regional Center for Mycology and Biotechnology, Al-Azhar University, 11787 Nasr City, Cairo, Egypt.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2022 Jan 24; Vol. 2022, pp. 9246785. Date of Electronic Publication: 2022 Jan 24 (Print Publication: 2022).
DOI: 10.1155/2022/9246785
Abstrakt: Objective: The present study was aimed at investigating the possible antiulcer activities of some natural phytochemicals Aloe perryi leaf extract (APLE) and flower extract (APFE) in addition to the date palm seed extract (DPSE) and the oily samples of DPSE in a pylorus ligation-induced ulcer model using ranitidine as a standard antiulcer drug.
Background: Peptic ulcer is a prevalent gastrointestinal disorder due to hypersecretion of gastric acid. It affects four million people worldwide, and 2-10% of these ulcers are perforated and cause bleeding. This increases the risk of morbidity and mortality. So we aimed to introduce a primary study alternatively safe method for treating peptic ulcer.
Materials and Methods: Forty-two Wistar Albino rats of either sex were randomly divided into seven groups (6/each). The pylorus ligation was done to induce ulcer in pretreated albino rats. The antiulcer activities of extracts were estimated at different dose levels (250 and 500 mg/kg) using ranitidine as a standard drug (50 mg/kg). Gastric volume, pH, and total and free acidity as well as ulcer index and percentage of ulcer inhibition were measured to elucidate the antiulcerogenic effects. Histological examination of gastric ulcer was also performed. Statistical analysis for the results was done where P < 0.05 was considered statistically significant.
Results: Pylorus ligation for 6 h in control rats resulted in gastric ulcer which was indicated by the accumulation of gastric secretion and increased total acidity and decreased pH. The pretreatment of rats with APLE, APFE, and DPSE in addition to the oily samples of DPSE significantly inhibited the ulcers induced by pylorus ligation. These effects were attributed to significant reductions in total and free acidity, ulcer index, and gastric volume while there is a marked decrease in gastric pH (the antisecretory) as well as mucosal strengthening properties of these phytochemicals.
Conclusion: These findings give these extracts the potential to be a promising tool for the management of gastric ulcer after performing further clinical and experimental studies. Our study demonstrated the promising antiulcer activity of extracts and oils in pyloric ligation-induced gastric ulcer. To the best of our knowledge, this is the first study to explore the antiulcer activity of these extracts; however, further investigations may be recommended for full details about this antiulcerogenic capacity.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2022 Naif Al-Gabri et al.)
Databáze: MEDLINE
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