Resilience to the effects of social stress on vulnerability to developing drug addiction.
| Autor: | Calpe-López C; Department of Psychobiology, University of Valencia, Valencia 46010, Spain., Martínez-Caballero MA; Department of Psychobiology, University of Valencia, Valencia 46010, Spain., García-Pardo MP; Faculty of Social and Human Sciences, University of Zaragoza, Teruel 44003, Spain., Aguilar MA; Department of Psychobiology, University of Valencia, Valencia 46010, Spain. asuncion.aguilar@uv.es. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of psychiatry [World J Psychiatry] 2022 Jan 19; Vol. 12 (1), pp. 24-58. Date of Electronic Publication: 2022 Jan 19 (Print Publication: 2022). |
| DOI: | 10.5498/wjp.v12.i1.24 |
| Abstrakt: | We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse. We define the concept of resilience and how it is applied to the field of drug addiction research. We also describe the internal and external protective factors associated with resilience, such as individual behavioral traits and social support. We then explain the physiological response to stress and how it is modulated by resilience factors. In the subsequent section, we describe the animal models commonly used in the study of resilience to social stress, and we focus on the effects of chronic social defeat (SD), a kind of stress induced by repeated experience of defeat in an agonistic encounter, on different animal behaviors (depression- and anxiety-like behavior, cognitive impairment and addiction-like symptoms). We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents. Finally, we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse, describing the current state of knowledge and suggesting future research directions. Competing Interests: Conflict-of-interest statement: The authors have no conflicts of interest to declare. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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