Total and free vitamin D status among apparently healthy adults living in Duhok Governorate.

Autor: Abdulrahman MA; Department of Public Health, College of Health and Medical Techniques, Duhok Polytechnic University, 61 Zakho Road, 1006 Mazi Qr., P.O.Box 101, Duhok, Kurdistan Region, Iraq. masood.abdulkareem@dpu.edu.krd., Alkass SY; Department of Medicinal Chemistry, College of Pharmacy, University of Duhok, Duhok, 1006 AJ, Iraq., Mohammed NI; Department of Medical Laboratory Technology, College of Health and Medical Techniques, Duhok Polytechnic University, Duhok, Iraq.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Feb 02; Vol. 12 (1), pp. 1778. Date of Electronic Publication: 2022 Feb 02.
DOI: 10.1038/s41598-022-05775-x
Abstrakt: Serum total 25-OHD is a main marker of vitamin D which represents the intake and sunlight exposure. Free form of 25-OHD, the small fraction not bound to a transporter protein has been incorporated as a new marker. This cross-sectional study aimed to evaluate the impact of several factors on total and free vitamin D levels in healthy subjects and to find out if the free form of vitamin D could be a better representative of the body's vitamin D status. Total and free 25-OHD were analyzed by ELISA method in a blood sample collected from 391 apparently healthy volunteers (219 female and 172 Male) from Duhok Governorate/Iraq population. Total and free 25-OHD levels were increased proportionally to BMI with lower values seen in the underweight group, also a significant gender differences in total D3 level with higher values in males (23.90 ± 16.41) ng/ml than females (21.24 ± 15.65) ng/ml was observed. Total and Free 25-OHD levels were significantly associated with ages, their deficiency most frequent occurs in the younger ages between (16-25) years old. Smokers had higher level of Total 25-OHD (26.95 ± 19.01) ng/ml and Free 25-OHD (9.47 ± 4.94) pg/ml than nonsmokers (22.14 ± 14.59) ng/ml and (7.87 ± 4.32) pg/ml respectively. A significant increase in Free 25-OHD level in the veiled women (9.12 ± 4.64) ng/ml than unveiled (6.16 ± 3.73) ng/ml with a significant positive correlation between Free 25-OHD level and dress style was also seen. 30% and 33% of the participants whom their daily exposure to sunlight for 30 min and > 1 h respectively were severe deficient in total 25-OHD. 95% of the participants who had Abnormally low level of free D were exposed for ≥ 30 min to sunlight. Daily exposure to sunlight was negatively associated with Free 25-OHD level.
(© 2022. The Author(s).)
Databáze: MEDLINE
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