The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland.

Autor:	Bell S; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, Scotland.; The Scottish Renal Registry, Scottish Health Audits, Public Health Scotland, Glasgow, Scotland.; Renal Unit, Ninewells Hospital, Dundee, Scotland., Campbell J; The Scottish Renal Registry, Scottish Health Audits, Public Health Scotland, Glasgow, Scotland., Lambourg E; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, Scotland., Watters C; The Scottish Renal Registry, Scottish Health Audits, Public Health Scotland, Glasgow, Scotland., O'Neil M; The Scottish Renal Registry, Scottish Health Audits, Public Health Scotland, Glasgow, Scotland., Almond A; Renal Unit, Mountainhall Treatment Centre, Dumfries, Scotland., Buck K; Renal Unit, Victoria Hospital, Kirkcaldy, Scotland., Carr EJ; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, Scotland.; Cell Biology of Infection Laboratory, Francis Crick Institute, London, United Kingdom., Clark L; Department of Renal Medicine, Foresterhill Health Campus, Aberdeen Royal Infirmary, Aberdeen, Scotland., Cousland Z; Renal Unit, Monklands Hospital, Airdrie, Scotland., Findlay M; Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, Scotland., Joss N; Renal Unit, Raigmore Hospital, Inverness, Scotland., Metcalfe W; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh Bioquarter, Edinburgh, Scotland., Petrie M; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh Bioquarter, Edinburgh, Scotland., Spalding E; Renal Unit, University Hospital Crosshouse, Crosshouse, Scotland., Traynor JP; Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, Scotland., Sanu V; Renal Unit, Ninewells Hospital, Dundee, Scotland., Thomson P; Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, Scotland., Methven S; Department of Renal Medicine, Foresterhill Health Campus, Aberdeen Royal Infirmary, Aberdeen, Scotland., Mark PB; Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, Scotland.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
Jazyk:	angličtina
Zdroj:	Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2022 Apr; Vol. 33 (4), pp. 677-686. Date of Electronic Publication: 2022 Feb 02.
DOI:	10.1681/ASN.2022010046
Abstrakt:	Background: Patients with kidney failure requiring KRT are at high risk of complications and death following SARS-CoV-2 infection, with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on the incidence of infection, hospitalization, and death from COVID-19 infection. Methods: The study design was an observational data linkage cohort study. Multiple health care datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses, and vaccine effectiveness were calculated. Results: As of September 19, 2021, 93% ( n =5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness rates against infection and hospitalization were 33% (95% CI, 0 to 52) and 38% (95% CI, 0 to 57), respectively. Within 28 days of a SARS-CoV-2-positive PCR test, 9.2% of fully vaccinated individuals died (7% patients on dialysis and 10% kidney transplant recipients). This compares to <0.1% of the vaccinated general Scottish population admitted to the hospital or dying due to COVID-19 during that period. Conclusions: These data demonstrate that a primary vaccine course of two doses has limited effect on COVID-19 infection and its complications in patients with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required. (Copyright © 2022 by the American Society of Nephrology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu