Ginger extract suppresses the activations of NF-κB and Wnt pathways and protects inflammatory arthritis.

Autor: Öz B; Department of Rheumatology, Fırat University School of Medicine, Elazığ, Turkey., Orhan C; Department of Animal Nutrition, Fırat University Faculty of Veterinary Science, Elazığ, Turkey., Tuzcu M; Department of Biology, Fırat University Faculty of Science, Elazığ, Turkey., Şahin N; Department of Animal Nutrition, Fırat University Faculty of Veterinary Science, Elazığ, Turkey., Özercan İH; Department of Pathology, Fırat University School of Medicine, Elazığ, Turkey., Demirel Öner P; Department of Microbiology, University of Health Sciences, Fethi Sekin City Hospital, Elazığ, Turkey., Koca SS; Department of Rheumatology, Fırat University School of Medicine, Elazığ, Turkey., Juturu V; Research and Development, OmniActive Health Technologies Inc., Morristown, NJ, USA., Şahin K; Department of Animal Nutrition, Fırat University Faculty of Veterinary Science, Elazığ, Turkey.
Jazyk: angličtina
Zdroj: European journal of rheumatology [Eur J Rheumatol] 2021 Oct; Vol. 8 (4), pp. 196-201.
DOI: 10.5152/eujrheum.2020.20192
Abstrakt: Objective: Rheumatoid arthritis (RA) is a disabling inflammatory disorder. Ginger is used for food and medicine to treat arthralgia, sprains, and muscle aches. Anti-inflammatory effects of ginger have been observed. The aim of our study was to detect the effects of ginger on experimentally induced inflammatory arthritis.
Methods: Female Wistar albino rats (n = 21) were randomly separated into three groups (control, arthritis, and arthritis + ginger). Arthritis was generated by an appropriate method using type 2 collagen and Freund's adjuvant (collagen-induced arthritis model). The ginger group was treated starting at the first collagen injection with ginger root extract for 32 days by oral gavage (50 mg/kg/daily). Interleukin (IL)-6, IL-17, tumor necrosis factor-α (TNF-α), sclerostin, dickkopf-related protein-1 (DKK-1), and obestatin serum levels were studied by enzyme-linked immunosorbent assay method. Tissue TNF-α, IL-17, cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) levels were detected using the Western blot method.
Results: Mean arthritis score and serum levels of TNF-α, IL-6, and IL-17 were significantly decreased in ginger group than in the arthritis group. Increased sclerostin serum level and decreased DKK-1 serum levels were detected in ginger group compared with arthritis group. The decreases of IL-17, TNF-α, COX-2, and NF-κB tissue levels were statistically significant in the ginger group compared with arthritis group. Histopathological evaluation of the ginger group showed a decrease in the inflammation score compared to arthritis group.
Conclusion: It can be concluded that ginger has protective properties in the development of inflammatory arthritis. The antiarthritic acts of ginger are related to NF-κB activity and Wnt pathway. Thus, it may be suggested that ginger is a candidate to research in human RA treatment.
Databáze: MEDLINE
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