The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies.

Autor: Zalpoor H; American Association of Kidney Patients, Tampa, FL, USA.; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.; Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Akbari A; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran., Samei A; Department of Laboratory Sciences, School of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran., Forghaniesfidvajani R; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran., Kamali M; Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Afzalnia A; Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Manshouri S; Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Heidari F; Immunology Department, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran., Pornour M; Department of Oncology, School of Medicine, University of Maryland, Maryland, USA., Khoshmirsafa M; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Iran, Iran., Aazami H; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Seif F; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran. farhad.seif@outlook.com.; Department of Immunology and Allergy, Academic Center for Education, Culture, and Research (ACECR), Enghelab St., Aboureyhan St., Vahid Nazari Crossroad, P17, 1315795613, Tehran, Iran. farhad.seif@outlook.com.
Jazyk: angličtina
Zdroj: Cellular & molecular biology letters [Cell Mol Biol Lett] 2022 Feb 02; Vol. 27 (1), pp. 10. Date of Electronic Publication: 2022 Feb 02.
DOI: 10.1186/s11658-022-00311-1
Abstrakt: The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases.
(© 2022. The Author(s).)
Databáze: MEDLINE
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